人类脑岛与海马体在记忆编码过程中的直接相互作用。

Direct interactions between the human insula and hippocampus during memory encoding.

作者信息

Huang Weichen, Lyu Dian, Stieger James R, Gotlib Ian H, Buch Vivek, Wagner Anthony D, Parvizi Josef

机构信息

Laboratory of Behavioral and Cognitive Neuroscience, Stanford University School of Medicine, Palo Alto, CA, USA.

Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Palo Alto, CA, USA.

出版信息

Nat Neurosci. 2025 Jul 14. doi: 10.1038/s41593-025-02005-1.

DOI:10.1038/s41593-025-02005-1

PMID:40659846

Abstract

The hippocampus is critical for encoding episodic memories, but how it interacts with cortical regions during this process remains unclear. In this study, 16 participants with implanted electrodes in the insula (217 sites) and hippocampus (131 sites) viewed emotionally valenced words and attempted to recall them. During encoding, one subset of insular neuronal populations showed changes in aperiodic activity that predicted successful recall. These insular changes followed hippocampal theta but preceded hippocampal ripples. Another subset of insular sites responded to word valence, unrelated to memory performance. Direct electrical stimulation of memory-related insular sites evoked early responses in the ipsilateral hippocampus, whereas stimulation of valence-related sites did not. Conversely, stimulating hippocampal sites produced slow, variable signals across all insular sites, suggesting asymmetric communication between the hippocampus and the insula. These findings provide a glimpse of mesoscale hippocampal interactions with functionally selective neuronal populations within a given cortical structure.

摘要

海马体对于情景记忆的编码至关重要，但在此过程中它如何与皮质区域相互作用仍不清楚。在这项研究中，16名在脑岛（217个位点）和海马体（131个位点）植入电极的参与者观看了带有情感效价的词语并试图回忆它们。在编码过程中，脑岛神经元群体的一个子集显示出非周期性活动的变化，这种变化预测了成功回忆。这些脑岛变化跟随海马体的theta波，但先于海马体的涟漪波。脑岛位点的另一个子集对词语效价有反应，与记忆表现无关。对与记忆相关的脑岛位点进行直接电刺激会在同侧海马体中引发早期反应，而对与效价相关的位点进行刺激则不会。相反，刺激海马体位点会在所有脑岛位点产生缓慢、可变的信号，表明海马体和脑岛之间存在不对称的交流。这些发现让我们得以一窥中尺度上海马体与给定皮质结构内功能选择性神经元群体之间的相互作用。