Franklin Samuel P, Burke Emily E, Holmes Shannon P
Department of Small Animal Medicine and Surgery, Veterinary Teaching Hospital, University of Georgia, Athens, GA, USA; Regenerative Bioscience Center, University of Georgia, Athens, GA, USA.
Veterinary Biosciences and Diagnostic Imaging, University of Georgia , Athens, GA , USA.
Front Vet Sci. 2017 Feb 24;4:25. doi: 10.3389/fvets.2017.00025. eCollection 2017.
To determine whether assessment of morphological MRI sequences or delayed gadolinium-enhanced MRI of cartilage (dGEMRIC) would have strong correlations with arthroscopic assessment of cartilage pathology in dogs with naturally occurring medial compartment pathology of the elbow.
Dogs tentatively diagnosed with medial coronoid disease had evaluation of their affected elbows using radiography, morphological MRI sequences, and dGEMRIC MRI evaluation prior to arthroscopy. Elbow radiographs were graded 0-6 for severity of changes. Cartilage of the medial coronoid process (MCP) and humeral trochlea (HT) were scored on a 0-3 scale using anatomical MRI sequences. The T1 relaxation times for the MCP and trochlea were quantified using dGEMRIC. Cartilage pathology was graded arthroscopically using a modified Outerbridge score (MOS) by a surgeon blinded to MRI assessment. Correlations between radiography and MOS, and between MRI and MOS, were quantified.
Twenty-six elbows in 14 dogs were evaluated. There were statistically significant ( < 0.05) moderate correlations between radiographic scores and MOS for the MCP ( = 0.71) and HT (0.57). There was a statistically significant moderate correlation between morphological MRI scoring and MOS for the HT ( = 0.54; < 0.05), but not for the MCP ( > 0.05). There was a weak, but significant correlation, between the dGEMRIC value and MOS of the MCP ( = 0.41; < 0.05), but no correlation between the dGEMRIC values and MOS for the HT ( > 0.05).
Statistically significant correlations to MOS were identified for both radiography and MRI but neither diagnostic modality provided sufficiently strong correlations to serve as a substitute for arthroscopic evaluation of the articular cartilage.
确定形态学磁共振成像（MRI）序列评估或延迟钆增强软骨磁共振成像（dGEMRIC）与自然发生肘部内侧间室病变犬的关节镜下软骨病变评估之间是否具有强相关性。
初步诊断为内侧冠状突疾病的犬在关节镜检查前，对其患侧肘部进行放射摄影、形态学MRI序列评估和dGEMRIC MRI评估。根据变化严重程度将肘部X线片评为0 - 6级。使用解剖学MRI序列，将内侧冠状突（MCP）和肱骨滑车（HT）的软骨按0 - 3级评分。使用dGEMRIC对MCP和滑车的T1弛豫时间进行量化。由对MRI评估不知情的外科医生使用改良的Outerbridge评分（MOS）对关节镜下软骨病变进行分级。对放射摄影与MOS之间以及MRI与MOS之间的相关性进行量化。
对14只犬的26个肘部进行了评估。MCP的放射学评分与MOS之间（= 0.71）以及HT的放射学评分与MOS之间（0.57）存在统计学显著（< 0.05）的中度相关性。HT的形态学MRI评分与MOS之间存在统计学显著的中度相关性（= 0.54；< 0.05），但MCP的形态学MRI评分与MOS之间无相关性（> 0.05）。MCP的dGEMRIC值与MOS之间存在弱但显著的相关性（= 0.41；< 0.05），但HT的dGEMRIC值与MOS之间无相关性（> 0.05）。
放射摄影和MRI与MOS均存在统计学显著相关性，但两种诊断方式均未提供足够强的相关性以替代关节镜对关节软骨的评估。
