Department of Laboratory Medicine, West China Hospital Affiliated to Sichuan University, Chengdu, China.
Department of Rheumatology, West China Hospital Affiliated to Sichuan University, Chengdu, China.
J Immunol Res. 2017;2017:5096741. doi: 10.1155/2017/5096741. Epub 2017 Feb 12.
Systemic lupus erythematosus (SLE) is an autoimmune disease with great heterogeneity in pathogenesis and clinical symptoms. Rheumatoid factor (RF) is one key indicator for rheumatoid arthritis (RA) while immunoglobulin E (IgE) is associated with type I hypersensitivity. To better categorize SLE subtypes, we determined the dominant cytokines based on familial SLE patients. RF, IgE, and multiple cytokines (i.e., IL-1, IL-6, IL-8, IL-10, IL-17, IFN-, IP-10, MCP-1, and MIP-1) were measured in sera of familial SLE patients ( = 3), noninherited SLE patients ( = 108), and healthy controls ( = 80). Three familial SLE patients and 5 noninherited SLE cases are with features of RF+IgE+. These RF+IgE+ SLE patients expressed significantly higher levels of IL-1 and IL-6 than the other SLE patients ( < 0.05). IL-6 correlated with both IgE and IL-1 levels in RF+IgE+ SLE patients ( = 0.583, = 0.027; = 0.847, = 0.001), and IgE also correlated with IL-1 ( = 0.567, = 0.031). Both IL-1 and IL-6 are highly expressed cytokines in RF+IgE+ SLE subtype which may be related to the pathogenesis of this special SLE subtype and provide accurate treatment strategy by neutralizing IL-1 and IL-6.
系统性红斑狼疮（SLE）是一种自身免疫性疾病，其发病机制和临床表现具有很大的异质性。类风湿因子（RF）是类风湿关节炎（RA）的一个关键指标，而免疫球蛋白 E（IgE）与 I 型超敏反应有关。为了更好地对SLE 亚型进行分类，我们根据家族性 SLE 患者确定了主要的细胞因子。我们检测了家族性 SLE 患者（n=3）、非遗传性 SLE 患者（n=108）和健康对照者（n=80）血清中的 RF、IgE 和多种细胞因子（即 IL-1、IL-6、IL-8、IL-10、IL-17、IFN-γ、IP-10、MCP-1 和 MIP-1）。在 3 名家族性 SLE 患者和 5 名非遗传性 SLE 患者中发现了 RF+IgE+的特征。这些 RF+IgE+ SLE 患者的 IL-1 和 IL-6 表达水平明显高于其他 SLE 患者（P<0.05）。IL-6 与 RF+IgE+ SLE 患者的 IgE 和 IL-1 水平均呈正相关（r=0.583，P=0.027；r=0.847，P=0.001），IgE 也与 IL-1 呈正相关（r=0.567，P=0.031）。在 RF+IgE+ SLE 亚型中，IL-1 和 IL-6 是高表达的细胞因子，这可能与这种特殊的 SLE 亚型的发病机制有关，并通过中和 IL-1 和 IL-6 提供准确的治疗策略。
