a Department of Cardiology , West China Hospital, Sichuan University , Chengdu , Sichuan , China.
b Division of Reproductive Medical Center , West China Second University Hospital, Sichuan University , Chengdu , Sichuan , China.
Clin Exp Hypertens. 2017;39(2):175-182. doi: 10.1080/10641963.2016.1235177. Epub 2017 Mar 1.
The endothelial nitric oxide synthase (eNOS) gene plays an important role in regulating vascular tone and blood pressure. Recently, the eNOS G894T and T-786C single nucleotide polymorphisms (SNPs) were intensively studied with regard to their associations with hypertension. However, the results of these studies were inconsistent. Therefore, we conducted the so far largest meta-analysis to better assess the correlations between eNOS SNPs and hypertension. Eligible articles were searched in PubMed, Medline, Embase, Scopus, and CNKI up to April 2016. Odds ratios (ORs) and 95% confidence intervals (CIs) were used to detect any potential associations between eNOS SNPs and the risk of hypertension. A total of 95 case-control studies involving 29,308 hypertension cases and 33,950 healthy controls were analyzed. The overall meta-analysis results showed that eNOS G894T and T-786C SNPs were both significantly associated with the risk of hypertension, the T allele of G894T SNP (G versus T, P < 0.00001, OR = 0.82, 95% CI 0.76-0.89) and C allele of T-786C SNP (T versus C, P = 0.004, OR = 0.92, 95% CI 0.87-0.97) conferred an increased susceptibility to hypertension. Further subgroup analyses yielded similar positive results for G894T SNP in essential hypertension, gestational hypertension, and Asian ethnicity, and that for T-786C SNP in essential hypertension and Asian population. Overall, our findings suggest that eNOS G894T and T-786C SNPs were both significantly correlated with hypertension. Additionally, the T allele of G894T SNP and C allele of T-786C SNP may serve as potential biological markers for hypertension susceptibility in Asians.
内皮型一氧化氮合酶（eNOS）基因在调节血管张力和血压方面起着重要作用。最近，eNOS G894T 和 T-786C 单核苷酸多态性（SNPs）与高血压的相关性受到了广泛的研究。然而，这些研究的结果并不一致。因此，我们进行了迄今为止最大的荟萃分析，以更好地评估 eNOS SNPs 与高血压之间的相关性。在 PubMed、Medline、Embase、Scopus 和中国知网（CNKI）中检索了截至 2016 年 4 月的符合条件的文章。使用比值比（ORs）和 95%置信区间（CIs）来检测 eNOS SNPs 与高血压风险之间的任何潜在关联。分析了总共 95 项病例对照研究，包括 29308 例高血压病例和 33950 例健康对照。总体荟萃分析结果表明，eNOS G894T 和 T-786C SNPs 均与高血压风险显著相关，G894T SNP 的 T 等位基因（G 对 T，P < 0.00001，OR = 0.82，95%CI 0.76-0.89）和 T-786C SNP 的 C 等位基因（T 对 C，P = 0.004，OR = 0.92，95%CI 0.87-0.97）增加了患高血压的易感性。进一步的亚组分析在原发性高血压、妊娠期高血压和亚洲人群中得出了 G894T SNP 的类似阳性结果，在原发性高血压和亚洲人群中得出了 T-786C SNP 的类似阳性结果。总体而言，我们的研究结果表明，eNOS G894T 和 T-786C SNPs 均与高血压显著相关。此外，G894T SNP 的 T 等位基因和 T-786C SNP 的 C 等位基因可能是亚洲人群高血压易感性的潜在生物学标志物。
