Departments of †Chemistry, ‡Mechanical Engineering and Materials Science, §Environmental and Occupational Health, and ∥Bioengineering, University of Pittsburgh , Pittsburgh, Pennsylvania 15260, United States.
J Am Chem Soc. 2017 Apr 5;139(13):4859-4865. doi: 10.1021/jacs.7b00390. Epub 2017 Mar 22.
Single-walled carbon nanotubes (SWCNTs) have been incorporated in many emerging applications in the biomedical field including chemical sensing, biological imaging, drug delivery, and photothermal therapy. To overcome inherent hydrophobicity and improve their biocompatibility, pristine SWCNTs are often coated with surfactants, polymers, DNA, proteins, or lipids. In this paper, we report the effect of polyunsaturated fatty acids (PUFAs) on SWCNT photoluminescence. A decrease in the SWCNT bandgap emission (E) and a new red-shifted emission (E) were observed in the presence of PUFAs. We attribute the change in SWCNT photoluminescence to the formation of oxygen-containing defects by lipid hydroperoxides through photo-oxidation. The observed changes in near-infrared emission of SWCNTs are important for understanding the interaction between SWCNTs and lipid biocorona. Our results also indicate that photoexcited SWCNTs can catalyze lipid peroxidation similarly to lipoxygenases.
单壁碳纳米管（SWCNTs）已经在许多新兴的生物医学应用中得到了应用，包括化学传感、生物成像、药物输送和光热治疗。为了克服固有的疏水性并提高其生物相容性，原始的 SWCNTs 通常用表面活性剂、聚合物、DNA、蛋白质或脂质进行涂层处理。在本文中，我们报告了多不饱和脂肪酸（PUFAs）对 SWCNT 光致发光的影响。在存在 PUFAs 的情况下，观察到 SWCNT 带隙发射（E）的降低和新的红移发射（E）。我们将 SWCNT 光致发光的变化归因于脂质过氧化物通过光氧化形成含氧缺陷。SWCNTs 的近红外发射的观察到的变化对于理解 SWCNTs 与脂质生物冠之间的相互作用很重要。我们的结果还表明，光激发的 SWCNTs 可以像脂氧合酶一样催化脂质过氧化。
