Department of Life Sciences, Pohang University of Science and Technology, Pohang 37673, Korea.
Department of Life Sciences, and School of Interdisciplinary Bioscience and Bioengineering, Pohang University of Science and Technology, Pohang 37673, Korea.
BMB Rep. 2017 Apr;50(4):160-161. doi: 10.5483/bmbrep.2017.50.4.045.
Proper maintenance of biological components is crucial for longevity and healthy aging. Although the role of homeostatic maintenance systems for DNA and protein in longevity is established, it remains largely unknown for RNA. In our recent work, we show that nonsense-mediated mRNA decay (NMD) promotes longevity in the roundworm C. elegans by enhancing RNA quality control. We find that the activity of NMD decreases during aging, raising the possibility that RNA quality declines in old animals. We then show that key components of NMD complex are required for prolonged lifespan in C. elegans. In addition, animals with reduced insulin/insulin-like growth factor-1 (IGF-1) signaling (IIS), a representative longevity model, display increased NMD activity. Thus, up-regulation of NMD appears to play crucial roles in longevity conferred by reduced IIS via enhancing mRNA quality control. As both IIS and NMD pathways are evolutionarily conserved, mammals including humans may be equipped with similar RNA quality control systems to achieve longevity. [BMB Reports 2017; 50(4): 160-161].
生物组件的正确维护对于长寿和健康衰老至关重要。尽管 DNA 和蛋白质的体内平衡维持系统在长寿中的作用已得到确立，但 RNA 的作用在很大程度上仍不清楚。在我们最近的工作中，我们表明无意义介导的 mRNA 降解 (NMD) 通过增强 RNA 质量控制来促进秀丽隐杆线虫的长寿。我们发现 NMD 的活性随着衰老而降低，这增加了老年动物中 RNA 质量下降的可能性。然后，我们表明 NMD 复合物的关键组成部分对于秀丽隐杆线虫的寿命延长是必需的。此外，胰岛素/胰岛素样生长因子-1 (IGF-1) 信号转导 (IIS) 降低的代表性长寿模型动物显示出增加的 NMD 活性。因此，通过增强 mRNA 质量控制，NMD 的上调似乎在 IIS 降低所赋予的长寿中发挥着关键作用。由于 IIS 和 NMD 途径在进化上是保守的，包括人类在内的哺乳动物可能具有类似的 RNA 质量控制系统以实现长寿。[BMB 报告 2017;50(4):160-161]。
