Ponzoni Maurilio, Ferreri Andrés J M
Ateneo Vita Salute, Pathology Unit and Unit of Lymphoid Malignancies, San Raffaele Scientific Institute, Milan, Italy.
Department of Onco-Hematology and Unit of Lymphoid Malignancies, San Raffaele Scientific Institute, Milan, Italy.
Best Pract Res Clin Haematol. 2017 Mar-Jun;30(1-2):32-40. doi: 10.1016/j.beha.2017.01.001. Epub 2017 Jan 28.
In the last decades some bacteria have been associated with a various extent with marginal zone (extra nodal, nodal and splenic types) lymphomas are frequently associated with chronic infections, with important clinical, molecular, biological, and therapeutic implications. The well-known correlation between Helicobacter pylori and gastric MALT-lymphoma, the recently reported links between Chlamydia psittaci and ocular adnexal MALT-lymphoma and Borrelia burgdorferi and cutaneous MALT lymphoma constitute the most studied examples; in addition, Campylobacter jejuni and some more recent associations encompassing Achromobacter xylosoxidans and Haemophilus influenzae will be further reported. Biological and clinical features, therapeutic implications and future perspectives of these lymphoma-microbial associations are discussed in this review.
在过去几十年中，一些细菌在不同程度上与边缘区（结外、结内和脾型）淋巴瘤相关，这些淋巴瘤常与慢性感染有关，具有重要的临床、分子、生物学和治疗意义。幽门螺杆菌与胃黏膜相关淋巴组织淋巴瘤之间的著名关联，鹦鹉热衣原体与眼附属器黏膜相关淋巴组织淋巴瘤以及伯氏疏螺旋体与皮肤黏膜相关淋巴组织淋巴瘤之间最近报道的联系是研究最多的例子；此外，空肠弯曲菌以及一些包括木糖氧化无色杆菌和流感嗜血杆菌在内的最新关联也将进一步报道。本综述讨论了这些淋巴瘤与微生物关联的生物学和临床特征、治疗意义及未来展望。
