Unit of Lymphoid Malignancies, San Raffaele Scientific Institute, Milan, Italy; Division of Onco-Hematological Medicine, Department of Onco-Hematology, San Raffaele Scientific Institute, Milan, Italy.
Semin Cancer Biol. 2013 Dec;23(6):431-40. doi: 10.1016/j.semcancer.2013.09.004. Epub 2013 Sep 30.
A link with infectious agents, bacteria and viruses in particular, has been reported for many lymphoma entities. Marginal zone lymphomas (extranodal, nodal and splenic forms) are frequently associated with chronic infections, with important clinical, molecular, biological, and therapeutic implications. The well-known correlation between Helicobacter pylori and gastric MALT-lymphoma, the recently reported links between Chlamydophila psittaci and ocular adnexal MALT-lymphoma and Borrelia burgdorferi and cutaneous MALT lymphoma constitute the best studied examples of lymphomagenic activity of bacteria, while the hepatitis C virus represents the most extensively investigated virus associated with marginal zone lymphomas. Biological and clinical features, therapeutic implications and future perspectives of these lymphoma-microbial associations are discussed in this review.
许多淋巴瘤实体都与传染性病原体（尤其是细菌和病毒）有关。边缘区淋巴瘤（结外、结内和脾形式）常与慢性感染相关，具有重要的临床、分子、生物学和治疗意义。众所周知，幽门螺杆菌与胃黏膜相关淋巴组织（MALT）淋巴瘤之间存在相关性，最近报道的鹦鹉热衣原体与眼附属器 MALT 淋巴瘤以及伯氏疏螺旋体与皮肤 MALT 淋巴瘤之间存在相关性，这些都是细菌致淋巴瘤活性的最佳研究实例，而丙型肝炎病毒则是与边缘区淋巴瘤关联最广泛的病毒。本文就这些淋巴瘤-微生物相关性的生物学和临床特征、治疗意义及未来展望进行了讨论。
