Bain Anthony R, Barak Otto F, Hoiland Ryan L, Drvis Ivan, Bailey Damian M, Dujic Zeljko, Mijacika Tanja, Santoro Antoinette, DeMasi Daniel K, MacLeod David B, Ainslie Philip N
Centre for Heart Lung and Vascular Health, University of British Columbia, Kelowna, BC, Canada; Integrative Vascular Biology Laboratory, Colorado University, Boulder, United States.
School of Medicine, University of Split, Split, Croatia; Faculty of Medicine, University of Novi Sad, Serbia.
Respir Physiol Neurobiol. 2017 Aug;242:8-11. doi: 10.1016/j.resp.2017.02.015. Epub 2017 Mar 11.
The determining mechanisms of a maximal hyperoxic apnea duration in elite apneists have remained unexplored. We tested the hypothesis that maximal hyperoxic apnea duration in elite apneists is related to forced vital capacity (FVC) but not the central chemoreflex (for CO). Eleven elite apneists performed a maximal dry static-apnea with prior hyperoxic (100% oxygen) pre-breathing, and a central chemoreflex test via a hyperoxic re-breathing technique (hyperoxic-hypercapnic ventilatory response: HCVR); expressed as the increase in ventilation (pneumotachometry) per increase in arterial CO tension (PaCO; radial artery). FVC was assessed using standard spirometry. Maximal apnea duration ranged from 807 to 1262s (mean=1034s). Average HCVR was 2.0±1.2LminmmHg PaCO. The hyperoxic apnea duration was related to the FVC (r=0.45, p<0.05), but not the HCVR (r<0.01, p>0.05). These findings were interpreted to suggest that during a hyperoxic apnea, a larger initial lung volume prolongs the time before reaching intolerable discomfort associated with pending lung squeeze, while CO sensitivity has little impact.
精英屏气者最大高氧性呼吸暂停持续时间的决定机制尚未得到探索。我们检验了这样一个假设，即精英屏气者的最大高氧性呼吸暂停持续时间与用力肺活量（FVC）有关，而与中枢化学反射（针对二氧化碳）无关。11名精英屏气者在预先进行高氧（100%氧气）预呼吸后进行了最大程度的干式静态屏气，并通过高氧再呼吸技术进行了中枢化学反射测试（高氧-高碳酸通气反应：HCVR）；表示为动脉血二氧化碳张力（PaCO；桡动脉）每增加时通气量（呼吸流速仪）的增加。使用标准肺量计评估FVC。最大屏气持续时间为807至1262秒（平均 = 1034秒）。平均HCVR为2.0±1.2L·min⁻¹·mmHg⁻¹·PaCO₂⁻¹。高氧性呼吸暂停持续时间与FVC相关（r = 0.45，p<0.05），但与HCVR无关（r<0.01，p>0.05）。这些发现被解释为表明，在高氧性呼吸暂停期间，更大的初始肺容积会延长在因即将到来的肺挤压而产生无法忍受的不适之前的时间，而二氧化碳敏感性影响不大。
