Crumb3 极性蛋白。
The Crumbs3 Polarity Protein.
机构信息
Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan 48109-5680.
出版信息
Cold Spring Harb Perspect Biol. 2018 Mar 1;10(3):a027961. doi: 10.1101/cshperspect.a027961.
Abstract
The Crumbs proteins are evolutionarily conserved apical transmembrane proteins. Crumbs was discovered via its crucial role in epithelial polarity during fly embryogenesis. Crumbs proteins have variable extracellular domains but a highly conserved intracellular domain that can bind FERM and PDZ domain proteins. Mammals have three Crumbs genes and this review focuses on , the major Crumbs isoform expressed in mammalian epithelial cells. Although initial work has highlighted the role of Crumbs3 in polarity, more recent studies have found it has an important role in tissue morphogenesis functioning as a linker between the apical membrane and the actin cytoskeleton. In addition, recent publications have linked Crumbs3 to growth control via regulation of the Hippo/Yap pathway.
摘要
Crumb 蛋白是进化上保守的顶端跨膜蛋白。Crumb 蛋白在果蝇胚胎发生过程中对上皮极性具有关键作用，因此被发现。Crumb 蛋白具有可变的细胞外结构域，但具有高度保守的细胞内结构域，可与 FERM 和 PDZ 结构域蛋白结合。哺乳动物有三个 Crumb 基因，本综述主要关注在哺乳动物上皮细胞中表达的主要 Crumbs 同工型 。尽管最初的工作强调了 Crumbs3 在极性中的作用，但最近的研究发现它在组织形态发生中具有重要作用，作为顶端膜和肌动蛋白细胞骨架之间的连接物。此外，最近的出版物将 Crumbs3 与 Hippo/Yap 通路的调节联系起来，与生长控制有关。
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