Kilesso T Iu, Shobukhov V M, Papchikhin A V, Galegov G A
Mol Gen Mikrobiol Virusol. 1987 Oct(10):41-4.
The effect of nucleoside-5-triphosphates analogues on the DNA polymerase of herpes simplex virus (HSV) has been investigated. Evidence is obtained that 3-amino-2,3-dideoxythymidine triphosphate selectively inhibits the DNA synthesis, catalyzed by HSV DNA polymerase. 3-amino-2,3-dideoxythymidine exhibits antiherpetic effect in single cells cultures. It may be phosphorylated by cellular thymidine kinase. The nuclei of Vero cells infected by HSV are an adequate system for antiherpetic compounds screening.
已对核苷 - 5 - 三磷酸类似物对单纯疱疹病毒（HSV）DNA聚合酶的作用进行了研究。有证据表明，3 - 氨基 - 2,3 - 二脱氧胸苷三磷酸选择性抑制HSV DNA聚合酶催化的DNA合成。3 - 氨基 - 2,3 - 二脱氧胸苷在单细胞培养物中表现出抗疱疹作用。它可能被细胞胸苷激酶磷酸化。被HSV感染的Vero细胞核是筛选抗疱疹化合物的合适系统。
