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Nucleoside analogues with clinical potential in antivirus chemotherapy. The effect of several thymidine and 2'-deoxycytidine analogue 5'-triphosphates on purified human (alpha, beta) and herpes simplex virus (types 1, 2) DNA polymerases.

作者信息

Ruth J L, Cheng Y C

出版信息

Mol Pharmacol. 1981 Sep;20(2):415-22.

PMID:6272095
Abstract
摘要

相似文献

1
Nucleoside analogues with clinical potential in antivirus chemotherapy. The effect of several thymidine and 2'-deoxycytidine analogue 5'-triphosphates on purified human (alpha, beta) and herpes simplex virus (types 1, 2) DNA polymerases.具有抗病毒化疗临床潜力的核苷类似物。几种胸苷和2'-脱氧胞苷类似物5'-三磷酸对纯化的人（α，β）和单纯疱疹病毒（1型、2型）DNA聚合酶的作用。
Mol Pharmacol. 1981 Sep;20(2):415-22.
2
[Inhibitory effect of various analogs of nucleoside-5'-triphosphates on DNA synthesis catalyzed by DNA polymerase from herpes simplex virus type I].[核苷 - 5'-三磷酸各种类似物对单纯疱疹病毒I型DNA聚合酶催化的DNA合成的抑制作用]
Mol Gen Mikrobiol Virusol. 1987 Oct(10):41-4.
3
Differential inhibition of mammalian DNA polymerases alpha, beta and gamma and herpes simplex virus-induced DNA polymerase by the 5'-triphosphates of arabinosyladenine and arabinosylcytosine.阿拉伯糖基腺嘌呤和阿拉伯糖基胞嘧啶的5'-三磷酸对哺乳动物DNA聚合酶α、β和γ以及单纯疱疹病毒诱导的DNA聚合酶的差异抑制作用。
IARC Sci Publ (1971). 1978(24 Pt 2):999-1005.
4
Inhibition of herpes simplex virus-induced DNA polymerases and cellular DNA polymerase alpha by triphosphates of acyclic guanosine analogs.无环鸟苷类似物三磷酸盐对单纯疱疹病毒诱导的DNA聚合酶和细胞DNA聚合酶α的抑制作用。
Mol Pharmacol. 1986 Jun;29(6):614-21.
5
Herpes simplex virus type 2 induced pyrimidine nucleoside kinase: enzymatic basis for the selective antiherpetic effect of 5-halogenated analogues of deoxycytidine.2型单纯疱疹病毒诱导的嘧啶核苷激酶：脱氧胞苷5-卤代类似物选择性抗疱疹作用的酶学基础。
Biochemistry. 1978 Mar 7;17(5):920-8. doi: 10.1021/bi00598a028.
6
Newly synthesized L-enantiomers of 3'-fluoro-modified beta-2'-deoxyribonucleoside 5'-triphosphates inhibit hepatitis B DNA polymerases but not the five cellular DNA polymerases alpha, beta, gamma, delta, and epsilon nor HIV-1 reverse transcriptase.新合成的3'-氟修饰的β-2'-脱氧核糖核苷5'-三磷酸的L-对映体可抑制乙型肝炎DNA聚合酶，但对五种细胞DNA聚合酶α、β、γ、δ和ε以及HIV-1逆转录酶无抑制作用。
J Med Chem. 1998 Jun 4;41(12):2040-6. doi: 10.1021/jm9704210.
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Chiral discrimination of enantiomeric 2'-deoxythymidine 5'-triphosphate by HIV-1 reverse transcriptase and eukaryotic DNA polymerases.HIV-1逆转录酶和真核DNA聚合酶对映体2'-脱氧胸苷5'-三磷酸的手性识别
Biochem Biophys Res Commun. 1994 Apr 29;200(2):1023-7. doi: 10.1006/bbrc.1994.1552.
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Differential substrate specificity of DNA polymerase beta and of a DNA polymerase induced by herpes simplex virus type 2 towards thymidine triphosphate analogues.
J Gen Virol. 1984 Mar;65 ( Pt 3):467-75. doi: 10.1099/0022-1317-65-3-467.
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[Inhibitory analysis of DNA polymerase of herpes simplex type 1].[单纯疱疹病毒1型DNA聚合酶的抑制分析]
Mol Biol (Mosk). 1994 Jul-Aug;28(4):875-86.
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Inhibitory effects of 2'-deoxy-L-thymidine 5'-triphosphate on human immunodeficiency virus reverse transcriptase and eukaryotic DNA polymerases.2'-脱氧-L-胸苷5'-三磷酸对人免疫缺陷病毒逆转录酶和真核DNA聚合酶的抑制作用。
Nucleic Acids Symp Ser. 1993(29):135-6.

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