Poole Matthew L, Brodtmann Amy, Darby David, Vogel Adam P
Centre for Neuroscience of Speech, The University of Melbourne, Victoria, AustraliaEastern Cognitive Disorders Clinic, Monash University, Melbourne, Victoria, Australia.
Eastern Cognitive Disorders Clinic, Monash University, Melbourne, Victoria, AustraliaFlorey Institute for Neuroscience and Mental Health, Melbourne, Victoria, Australia.
J Speech Lang Hear Res. 2017 Apr 14;60(4):897-911. doi: 10.1044/2016_JSLHR-S-16-0140.
Our purpose was to create a comprehensive review of speech impairment in frontotemporal dementia (FTD), primary progressive aphasia (PPA), and progressive apraxia of speech in order to identify the most effective measures for diagnosis and monitoring, and to elucidate associations between speech and neuroimaging.
Speech and neuroimaging data described in studies of FTD and PPA were systematically reviewed. A meta-analysis was conducted for speech measures that were used consistently in multiple studies.
The methods and nomenclature used to describe speech in these disorders varied between studies. Our meta-analysis identified 3 speech measures which differentiate variants or healthy control-group participants (e.g., nonfluent and logopenic variants of PPA from all other groups, behavioral-variant FTD from a control group). Deficits within the frontal-lobe speech networks are linked to motor speech profiles of the nonfluent variant of PPA and progressive apraxia of speech. Motor speech impairment is rarely reported in semantic and logopenic variants of PPA. Limited data are available on motor speech impairment in the behavioral variant of FTD.
Our review identified several measures of speech which may assist with diagnosis and classification, and consolidated the brain-behavior associations relating to speech in FTD, PPA, and progressive apraxia of speech.
我们的目的是对额颞叶痴呆（FTD）、原发性进行性失语（PPA）和进行性言语失用症中的言语障碍进行全面综述，以确定诊断和监测的最有效措施，并阐明言语与神经影像学之间的关联。
系统回顾了FTD和PPA研究中描述的言语和神经影像学数据。对多项研究中一致使用的言语测量进行了荟萃分析。
这些疾病中描述言语的方法和术语在不同研究之间有所不同。我们的荟萃分析确定了3种言语测量方法，可区分不同变体或健康对照组参与者（例如，将PPA的非流利型和音韵性失写型变体与所有其他组区分开来，将行为变异型FTD与对照组区分开来）。额叶言语网络内的缺陷与PPA非流利型变体的运动言语特征和进行性言语失用症有关。PPA的语义型和音韵性失写型变体很少报告运动言语障碍。关于FTD行为变异型中运动言语障碍的数据有限。
我们的综述确定了几种言语测量方法，可能有助于诊断和分类，并巩固了FTD、PPA和进行性言语失用症中与言语相关的脑-行为关联。
