Codd E E, Walker R F
Department of Reproductive and Developmental Toxicology, Smith Kline and French Laboratories, Philadelphia, PA 19101.
NIDA Res Monogr. 1986;75:351-4.
Since pain and depression are influenced by opioids and antidepressants, it was of interest to explore their interaction with common CNS receptors. A method for binding site selectivity was used to evaluate antidepressant specificities in inhibiting mu versus delta opioid binding. With the very specific opioid probes used, DAGO and DPDPE, a wide range of antidepressant selectivities was found. These may represent different modes of interaction between mu and delta opioid sites and antidepressant compounds.
由于疼痛和抑郁会受到阿片类药物和抗抑郁药的影响，因此探索它们与常见中枢神经系统受体的相互作用很有意义。一种结合位点选择性的方法被用于评估抗抑郁药在抑制μ型与δ型阿片类药物结合方面的特异性。使用非常特异的阿片类药物探针DAGO和DPDPE，发现了广泛的抗抑郁药选择性。这些可能代表了μ型和δ型阿片类药物位点与抗抑郁药化合物之间不同的相互作用模式。
