Macedo Janus P F, Fernandes Leonardo L, Formiga Fábio R, Reis Michael F, Nagashima Júnior Toshiyuiky, Soares Luiz A L, Egito E Socrates T
Departmento de Farmácia-Programa de Pós Graduação em Ciências da Saúde-Laboratório de Sistemas Dispersos (LASID), Universidade Federal do Rio Grande do Norte, Rua Praia de Areia Branca 8948, 59094-450, Natal-RN, Brazil.
AAPS PharmSciTech. 2006 Mar;7(1):E146-E152. doi: 10.1208/pt070121. Epub 2017 Mar 8.
The aim of this work was to develop a methodology for rapid determination of the critical hydrophilic-lipophilic balance (HLB) value of lipophilic fractions of emulsions. The emulsions were prepared by the spontaneous emulsification process with HLB value from 4.3 to 16.7. The preparations were stored at 2 different temperatures (25°C and 4°C) and their physicochemical behavior was evaluated by the micro-emultocrit technique and the long-term stability study. The experimental data show a reverse relationship between HLB values of the surfactant mixtures and emulsion stability. A close correlation between the results for both stability procedures was observed, suggesting the use of micro-emultocrit to predict stabilities of such systems. In addition, it was found that the critical HLB of the Mygliol 812 was 15.367.
这项工作的目的是开发一种快速测定乳液亲脂性部分临界亲水亲油平衡（HLB）值的方法。通过自发乳化过程制备HLB值为4.3至16.7的乳液。制剂在2个不同温度（25°C和4°C）下储存，并通过微乳液临界技术和长期稳定性研究评估其物理化学行为。实验数据表明表面活性剂混合物的HLB值与乳液稳定性之间呈反比关系。观察到两种稳定性程序的结果之间存在密切相关性，表明使用微乳液临界技术来预测此类系统的稳定性。此外，发现Miglyol 812的临界HLB为15.367。
