Lopes Pablo Queiroz, Carneiro Fabíola Bernardo, de Sousa Ana Letícia Braz, Santos Sócrates Golziodo, Oliveira Elquio Eleamen, Soares Luiz Alberto Lira
Programa de Pós-Graduação em Ciências Farmacêuticas, Universidade Federal de Pernambuco - UFPE, Rua Prof. Artur de Sá s/n, Recife, Pernambuco, Brazil.
Departamento de Ciências Farmacêuticas, Universidade Federal da Paraíba - UFPB, Cidade Universitária, João Pessoa, Paraíba, Brazil.
Pharmacogn Mag. 2017 Jan-Mar;13(49):159-167. doi: 10.4103/0973-1296.197646.
Lour is a species which is widespread throughout tropical countries where it is widely used against respiratory tract disorders such as bronchodilator, antitussive, and expectorant conditions.
This study aims to characterize the essential oil of (PaEO) and produce and evaluate emulsions containing PaEO.
The essential oil was characterized by physical-chemical analyses for density, refractive index, 90% ethanol solubility, color, appearance, and identification by gas chromatography coupled to mass spectrometry detection. The emulsions were prepared following a hydrophile-lipophile balance [HLB] spreadsheet design from two nonionic surfactants (Span 80 and Tween 20) producing HLB values ranging from 4.3 to 16.7. The products were stored at room temperature at 5°C. The emulsion stabilities were tested both in the long and short-term.
The PaEO was obtained by steam distillation and the total extraction was reached after 3 hours yielding of 0.2% (w/w). This essential oil was characterized by physicochemical analyses for density [1.5 g.ml], refraction index [0.9167], ethanol 90% solubility [1:2], color, and appearance (yellow/clear). Nineteen components were identified in the oil, among them the sesquiterpenes: carvacrol [33.50%], p-cymene [28.20%] and γ-terpinene [14.77%]. The emulsions obtained successfully showed, for the first time, HLB values for essential oils from [15.7].
The experimental data shows a relationship between HLB values of the surfactant mixtures contributing to the emulsified systems production containing phytopharmaceuticals. Such an approach is of great importance to the development of lipid carriers for therapeutic drugs.
The essential oil from leaves of was extracted by steam distillation and characterized.The emulsions containing essential oil were produced and the stability was performed in the short and long term.The critical hydrophilic-lipophilic balance (HLB) of the essential oil was 15.7 and was achieved by the combination of surfactants (Tween 80 and Span 20). PaEO: essential oil of , HLB: hydrophilic-lipophilic balance, CI: Creaming Index, MET: micro-emultocrit technique.
Lour是一种广泛分布于热带国家的植物，在这些国家它被广泛用于治疗呼吸道疾病，如作为支气管扩张剂、止咳剂和祛痰剂。
本研究旨在对Lour的精油（PaEO）进行表征，并制备和评估含有PaEO的乳液。
通过物理化学分析对精油的密度、折射率、90%乙醇溶解度、颜色、外观进行表征，并通过气相色谱-质谱联用检测进行鉴定。乳液按照亲水亲油平衡（HLB）电子表格设计，由两种非离子表面活性剂（司盘80和吐温20）制备，产生的HLB值范围为4.3至16.7。产品在5°C的室温下储存。对乳液的稳定性进行了短期和长期测试。
通过水蒸气蒸馏获得PaEO，3小时后总提取率达到0.2%（w/w）。该精油通过物理化学分析表征为密度[1.5 g/ml]、折射率[0.9167]、90%乙醇溶解度[1:2]、颜色和外观（黄色/澄清）。在该精油中鉴定出19种成分，其中倍半萜类：香芹酚[33.50%]、对伞花烃[28.20%]和γ-萜品烯[14.77%]。成功获得的乳液首次显示了Lour精油的HLB值为[15.7]。
实验数据表明，有助于生产含植物药乳化体系的表面活性剂混合物的HLB值之间存在关联。这种方法对治疗药物脂质载体的开发具有重要意义。
通过水蒸气蒸馏提取并表征了Lour叶片的精油。制备了含精油的乳液，并进行了短期和长期稳定性测试。精油的临界亲水亲油平衡（HLB）为15.7，通过表面活性剂（吐温80和司盘20）的组合实现。PaEO：Lour的精油，HLB：亲水亲油平衡，CI：乳析指数，MET：微乳析技术。
