Cognition and Brain Plasticity Group, Bellvitge Biomedical Research Institute-IDIBELL, L'Hospitalet de Llobregat, 08907, Barcelona, Spain.
Neuro-Oncology Unit, Hospital Universitari de Bellvitge-ICO L'Hospitalet-IDIBELL, 08907, Barcelona, Spain.
Brain Imaging Behav. 2018 Apr;12(2):369-382. doi: 10.1007/s11682-017-9697-8.
The present study aimed to explore the functional connectivity differences in Resting State Networks (RSNs) induced by cancer and chemotherapy in Lung Cancer (LC) patients using an Independent Component Analysis (ICA). Three matched groups of 15 LC patients following Chemotherapy (C+), 15 LC patients before Chemotherapy (C-) and 15 Healthy Controls (HC) were included. Analysis was performed using ICA and a multivariate pattern analysis (MVPA) to classify groups based on profiles of functional connectivity. We found significant differences in four of the RSN identified: Default Mode Network (DMN), Predominantly Left and Right Anterior Temporal Network, and Cerebellum Network. Whereas DMN showed decreased connectivity, the other RSNs exhibited increased connectivity in both LC groups compared to HC and in C+ in comparison to C-. MVPA discriminated significantly and accurately between all groups. Our study showed that disrupted functional connectivity associated with cancer and chemotherapy-induced cognitive deficits is not only related to DMN decreased connectivity abnormalities but also to an increased connectivity of other RSNs, suggesting a potential compensatory mechanism. Graphical abstract.
本研究旨在使用独立成分分析（ICA）探讨癌症和化疗引起的肺癌（LC）患者静息态网络（RSN）的功能连接差异。纳入了三组 15 名化疗后（C+）、15 名化疗前（C-）和 15 名健康对照（HC）的 LC 患者。采用 ICA 和多变量模式分析（MVPA）对功能连接图谱进行分类，对三组进行分析。我们发现，在确定的四个 RSN 中存在显著差异：默认模式网络（DMN）、主要左/右前颞网络和小脑网络。与 DMN 连接减少相反，与 HC 相比，两个 LC 组和 C+与 C-相比，其他 RSN 的连接均增加。MVPA 可以显著准确地对所有组进行区分。我们的研究表明，与癌症和化疗引起的认知缺陷相关的功能连接中断不仅与 DMN 连接异常减少有关，而且与其他 RSN 的连接增加有关，提示存在潜在的代偿机制。
