Russell R D, Leslie J B, Su Y F, Watkins W D, Chang K J
Department of Anesthesiology, Duke University Medical Center, Durham, N.C. 27710.
NIDA Res Monogr. 1986;75:97-100.
Possible interactions between mu- and delta-receptors in the rat spinal cord were studied using the radiant-heat-induced tail flick response and the highly selective mu- or delta-ligands: [NMePhe3,D-Pro4] morphiceptin(PL-17) and cyclic[D-Pen2,D-Pen5]enkephalin(DPDPE). Intrathecal infusions of PL-17 (0.5 microgram/hr) for 5 days caused 61- and 6-fold shifts to the right of the dose-response curves for PL-17 and DPDPE, respectively. Since PL-17 and DPDPE are highly selective agonists for mu- and delta-receptors, the partial cross-tolerance to the delta-agonist induced by PL-17 is probably not resultant from a cross-reactivity between these ligands. These data suggest that there may be an interaction between mu- and delta-receptors in the rat spinal cord.
利用辐射热诱导的甩尾反应以及高选择性的μ或δ配体：[NMePhe3，D-Pro4]吗啡肽（PL-17）和环[D-Pen2，D-Pen5]脑啡肽（DPDPE），研究了大鼠脊髓中μ受体和δ受体之间可能的相互作用。鞘内注射PL-17（0.5微克/小时），持续5天，分别使PL-17和DPDPE的剂量反应曲线向右移动了61倍和6倍。由于PL-17和DPDPE分别是μ受体和δ受体的高选择性激动剂，PL-17诱导的对δ激动剂的部分交叉耐受性可能并非源于这些配体之间的交叉反应性。这些数据表明，大鼠脊髓中μ受体和δ受体之间可能存在相互作用。
