Rapaka R S, Porreca F
Division of Preclinical Research, National Institute on Drug Abuse, Rockville, Maryland 20857.
Pharm Res. 1991 Jan;8(1):1-8. doi: 10.1023/a:1015809702296.
Although much effort has been devoted to opioid research since the identification of enkephalins, understanding of the physiological importance and mechanisms of action of endogenous opioids lags behind understanding of opiate alkaloids such as morphine. In recent years, several novel approaches have been refined with promise for the successful development of the long-awaited nonaddicting analgesics that act at the opioid delta receptor. The present communication reviews these efforts.
自从脑啡肽被发现以来，尽管在阿片类药物研究方面投入了大量精力，但对内源性阿片类物质的生理重要性及作用机制的理解仍落后于对吗啡等阿片生物碱的理解。近年来，几种新方法得到了改进，有望成功开发出人们期待已久的作用于阿片δ受体的非成瘾性镇痛药。本通讯综述了这些研究成果。
