Spinal Cord Injury Service and Disorders, Hunter Holmes McGuire VA Medical Center, Richmond, VA, USA -
Department Physical Medicine and Rehabilitation, Virginia Commonwealth University, Richmond, VA, USA -
Eur J Phys Rehabil Med. 2017 Aug;53(4):625-629. doi: 10.23736/S1973-9087.17.04452-5. Epub 2017 Mar 13.
Mesenchymal stem cells can be differentiated into muscle satellite cells. Testosterone replacement therapy (TRT) promotes the differentiation of satellite cells into muscle cells.
A 31-year-old male with a T4 complete chronic spinal cord injury (SCI) had fixation for a mid-shaft fracture of the left femur. The participant received transdermal testosterone patches (4 mg/day) daily for 16 weeks. Skeletal muscle and yellow bone marrow adiposity cross-sectional areas (CSAs) of both thighs were measured using magnetic resonance imaging.
The yellow bone marrow CSA was 67-69% lower in the left femur compared to the right femur. Following intervention, a discrepancy was noted between the whole skeletal muscle CSAs of the right (+13%) and left (+6%) thighs. The right knee extensor CSA increased by 7% with no changes in the left CSA. Disruption in bone marrow fat may attenuate the systemic effects of TRT on muscle size.
间充质干细胞可分化为肌肉卫星细胞。睾丸素替代疗法（TRT）可促进卫星细胞向肌细胞分化。
一名 31 岁男性，T4 完全慢性脊髓损伤（SCI），左侧股骨中段骨折固定。该参与者每天接受透皮睾丸素贴片（4 毫克/天）治疗 16 周。使用磁共振成像测量双侧大腿的骨骼肌和黄骨髓脂肪横截面积（CSA）。
与右侧股骨相比，左侧股骨的黄骨髓 CSA 低 67-69%。干预后，右侧（+13%）和左侧（+6%）大腿的整个骨骼肌 CSA 之间出现差异。右膝伸肌 CSA 增加了 7%，而左侧 CSA 没有变化。骨髓脂肪的破坏可能会减弱 TRT 对肌肉大小的全身影响。
