八面体钌配合物具有独特的金属手性中心，用于高效不对称催化。
Octahedral Ruthenium Complex with Exclusive Metal-Centered Chirality for Highly Effective Asymmetric Catalysis.
机构信息
Fachbereich Chemie, Philipps-Universität Marburg , Hans-Meerwein-Strasse 4, 35043 Marburg, Germany.
出版信息
J Am Chem Soc. 2017 Mar 29;139(12):4322-4325. doi: 10.1021/jacs.7b01098. Epub 2017 Mar 20.
PMID:28290685
Abstract
A novel ruthenium catalyst is introduced which contains solely achiral ligands and acquires its chirality entirely from octahedral centrochirality. The configurationally stable catalyst is demonstrated to catalyze the alkynylation of trifluoromethyl ketones with very high enantioselectivity (up to >99% ee) at low catalyst loadings (down to 0.2 mol%).
摘要
介绍了一种新型的钌催化剂，它仅含有手性配体，完全从八面体中心手性获得其手性。该构型稳定的催化剂被证明可在低催化剂负载量（低至 0.2 mol%）下，以非常高的对映选择性（高达>99%ee）催化三氟甲基酮的炔基化反应。
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