Ryabikhin Ryabikhin, Mozheiko M E, Krasilnikova Y
Yaroslavl Regional Clinical Hospital of Wars Veterans, International Center for Elderly Problems Zdorovoe Dolgoletie, Yaroslavl, Russia.
Kardiologiia. 2016 Dec;56(11):12-17. doi: 10.18565/cardio.2016.11.12-17.
To study the effect of nicorandil on the elasticity of the great vessels, cardiac functional parameters and quality of life in patients with coronary heart disease (CHD).
In a double-blind, randomized, placebo-controlled trial of nicorandil was attended by 154 patients with stable angina III functional class (FC), divided into 2 comparable age and sex group. Study duration was 12 months.
In the group treated with nicorandil compared with placebo, the number of angina attacks and nitrate intake of short-significantly reduced, improved elastic properties of large arteries, improved quality of life. In a cohort of patients with CHD and left ventricular ejection fraction less than 45% nikorandil addition to standard therapy has improved the systolic function of the heart and reduce left ventricular remodeling.
The use of nicorandil in addition to standard therapy can not only improve the quality of life in patients with coronary artery disease, but also a positive impact on the state of elasticity of blood vessels and morpho-functional parameters of the heart.
研究尼可地尔对冠心病（CHD）患者大血管弹性、心脏功能参数及生活质量的影响。
在一项双盲、随机、安慰剂对照试验中，154例III级功能分级（FC）的稳定型心绞痛患者参与了尼可地尔试验，分为2个年龄和性别可比组。研究持续时间为12个月。
与安慰剂组相比，尼可地尔治疗组心绞痛发作次数和短效硝酸酯类药物摄入量显著减少，大动脉弹性特性改善，生活质量提高。在冠心病且左心室射血分数小于45%的患者队列中，在标准治疗基础上加用尼可地尔改善了心脏收缩功能并减少了左心室重构。
在标准治疗基础上加用尼可地尔不仅可以改善冠心病患者的生活质量，还对血管弹性状态及心脏形态功能参数有积极影响。
