[圣彼得堡代谢健康型肥胖居民（ESSE-RF）中的脂肪因子水平]

[Adipokines Level in Metabolically Healthy Obese Saint-Petersburg Inhabitants (ESSE-RF)].

作者信息

Boyarinova M A, Orlov A V, Rotar O P, Alieva A S, Moguchaya E V, Vasileva E U, Soltsev V N, Baranova E I, Konradi A O

机构信息

Almazov Federal North-West Medical Research Centre, Saint Petersburg, Russia.

出版信息

Kardiologiia. 2016 Aug;56(8):40-45. doi: 10.18565/cardio.2016.8.40-45.

DOI:10.18565/cardio.2016.8.40-45

PMID:28290879

Abstract

AIM

to elucidate prevalence of phenotypes of metabolically heathy obesity (MHO) among inhabitants of Saint-Petersburg using various criteria and assess dependence levels of adipokines on obesity phenotype.

MATERIAL AND METHODS

Within a framework of epidemiologic study ESSE-RF we formed a random sample of 1600 Saint-Petersburg inhabitants stratified according to gender and age. Examination of participants included anthropometry with measurement of waist circumference CRP and estimation of body mass index (BMI), measurement of arterial pressure, determination of fasting blood glucose, insulin (with calculation of index of insulin resistance -IIR), lipid spectrum, C-reactive protein (CRP), adiponectin, leptin. In subjects with obesity (BMI more or equal 30 kg/m) we used Meigs and Wildman MHO criteria. To Wildman criteria we applied 3 variants of definition of elevated CRP and IIR: 90th percentile among subjects with BMI <25 kg/m (variant 1) or among all participants (variant 2), and (variant 3) definition from publication by E.Oliveros et al. (2014).

RESULTS

Obesity (BMI more or equal 30 kg/m) was found in 430 participants. Numbers/rates of MHO according to the Wildman criteria were the following: variant 1 - 49/12% (among them 13/10% men and 36/14% women, =0.15); variant 2 - 85/22% (24/18% men, 61/23% women, =0.13); variant 3 - 59/15% (13/10% men, 46/18% women, =0.02). Portion of MHO according to Meigs criteria was 138/35% (among them 48/36% men, 90/35% women, =0.4). Significant differences in adipokines levels between subjects with MHO and metabolically unhealthy obesity (MUHO) were revealed only among women. There was no difference in leptin level between subjects with MHO and MUHO irrespective of gender.

CONCLUSION

Rate of MHO phenotype in a sample of inhabitants of Saint-Petersburg varied from 12 to 35% depending on criteria used. Gender differences in MHO rates were minimal and depended on selected criteria. Elevated adiponectin level among obese women could be presumably related to more favorable metabolic profile.

摘要

目的

使用各种标准阐明圣彼得堡居民中代谢健康型肥胖（MHO）表型的患病率，并评估脂肪因子对肥胖表型的依赖程度。

材料与方法

在流行病学研究ESSE-RF的框架内，我们形成了一个1600名圣彼得堡居民的随机样本，该样本根据性别和年龄进行了分层。对参与者的检查包括人体测量（测量腰围、CRP并估算体重指数（BMI））、测量动脉血压、测定空腹血糖、胰岛素（计算胰岛素抵抗指数-IIR）、血脂谱、C反应蛋白（CRP）、脂联素、瘦素。在肥胖受试者（BMI≥30kg/m²）中，我们使用了梅格斯和怀尔德曼的MHO标准。对于怀尔德曼标准，我们应用了CRP和IIR升高的3种定义变体：BMI<25kg/m²的受试者中的第90百分位数（变体1）或所有参与者中的第90百分位数（变体2），以及（变体3）E.奥利韦罗斯等人（2014年）发表的定义。

结果

在430名参与者中发现了肥胖（BMI≥30kg/m²）。根据怀尔德曼标准的MHO数量/比率如下：变体1 - 49/12%（其中男性13/10%，女性36/14%；P=0.15）；变体2 - 85/22%（男性24/18%，女性61/23%；P=0.13）；变体3 - 59/15%（男性13/10%，女性46/18%；P=0.02）。根据梅格斯标准的MHO比例为138/35%（其中男性48/36%，女性90/35%；P=0.4）。仅在女性中发现MHO受试者与代谢不健康型肥胖（MUHO）受试者之间的脂肪因子水平存在显著差异。无论性别如何，MHO受试者与MUHO受试者之间的瘦素水平均无差异。