Almazov North-West Federal Medical Research Centre, Akkuratova street 2, Saint-Petersburg, Russia.
Russian Cardiology Research and Production Complex, 3rd Cherepkovskaya, 15 A, Moscow, Russia.
Eur J Epidemiol. 2017 Mar;32(3):251-254. doi: 10.1007/s10654-016-0221-z. Epub 2016 Dec 30.
The aim of the study was to estimate the prevalence of metabolically healthy obese (MHO) and metabolically unhealthy non-obese (MUNO) phenotypes in Russian population.
In cross-sectional epidemiology survey "Epidemiology of cardiovascular diseases and its risk factors in some regions of the Russian Federation" a random sampling of 21,121 subjects (25-65 years), stratified by age and sex was involved. Anthropometry, blood pressure (BP) measurement and fasting blood-tests (glucose, lipids) were performed according to standard protocols. Criteria for MHO-body mass index (BMI) ≥30 kg/m and ≤2 of markers: HDL < 1.30 (females)/1.04 (males) mmol/l; triglycerides ≥1.7 mmol/l; glucose ≥5.6 mmol/l or treatment; waist >88 (females)/102 (males) cm and BP ≥ 130/85 mm Hg or therapy. Criteria for MUNO was BMI < 30 kg/m and ≥2 markers listed above. Simple tabulations, descriptive statistics, post-stratification weights and logistic regression were used for analyses.
MHO phenotype was detected in 2856 (41.5%) obese people; MUNO phenotype-in 4762 (34.4%) non-obese subjects. Aging was negatively associated with MHO and positively with MUNO prevalence. Gender was registered as determinant only of MUNO probability. No dramatic differences in lifestyle risk factors between 3 BMI groups (lean, overweight, obese) were found out.
Half of obese Russian inhabitants are metabolically healthy. At the same time, metabolic abnormalities were detected in one third of non-obese participants with a shift to male gender.
本研究旨在评估俄罗斯人群中代谢健康型肥胖（MHO）和代谢不健康非肥胖（MUNO）表型的流行率。
在横断面流行病学调查“俄罗斯联邦部分地区心血管疾病及其危险因素的流行病学”中，涉及了根据年龄和性别分层的 21121 名受试者（25-65 岁）的随机抽样。根据标准方案进行人体测量、血压（BP）测量和空腹血液检查（血糖、血脂）。MHO 的标准为：BMI≥30kg/m2 且≤2 项指标：HDL<1.30（女性）/1.04（男性）mmol/l；甘油三酯≥1.7mmol/l；血糖≥5.6mmol/l或治疗；腰围>88（女性）/102（男性）cm 和 BP≥130/85mmHg 或治疗。MUNO 的标准为 BMI<30kg/m2 且≥2 项上述指标。采用简单列表、描述性统计、后分层权重和逻辑回归进行分析。
2856 名（41.5%）肥胖者中检测到 MHO 表型；4762 名（34.4%）非肥胖者中检测到 MUNO 表型。年龄与 MHO 呈负相关，与 MUNO 呈正相关。性别仅被认为是 MUNO 概率的决定因素。在瘦、超重和肥胖三个 BMI 组之间未发现生活方式危险因素的显著差异。
一半的肥胖俄罗斯居民是代谢健康的。与此同时，在三分之一的非肥胖参与者中发现了代谢异常，且这种异常向男性性别转移。
