Niebuhr David W, Chen Ligong, Shao Stephanie, Goldsmith Jonathan, Byrne Celia, Singer Darrell E
Department of Preventive Medicine and Biostatistics, Uniformed Services of the Health Sciences, 4301 Jones Bridge Road, Bethesda, MD 20814.
Office of New Drugs, Center for Drug Evaluation and Research, Food and Drug Administration, Department of Health and Human Services, Mail Stop 6311, 10903 New Hampshire Avenue, Silver Spring, MD 20993.
Mil Med. 2017 Mar;182(3):e1819-e1824. doi: 10.7205/MILMED-D-16-00136.
Population-based estimates of sickle cell trait (SCT) prevalence in the U.S. military across services and over time are lacking.
SCT prevalence by service, race/ethnicity, and gender in 5-year time intervals was estimated using demographic, ambulatory, and hospital SCT encounter (International Classification of Diseases, 9th Revision, Clinical Modification 282.5) data for active duty, enlisted between 1992 and 2012 and limited SCT laboratory results.
Our study identified 15,081 SCT subjects. SCT prevalence varied significantly by race, year, gender, and service branch. SCT prevalence was highest for non-Hispanic blacks (5.02%; prevalence ratio = 56.33, confidence interval [CI] = 52.14-60.85; compared to non-Hispanic white) in 2005-2009 (0.40%; prevalence ratio = 10.04, CI = 9.21-10.94; compared to 1992-1994), for women (2.97%; prevalence ratio = 3.14, CI = 3.04-3.25; compared to men), and in the Navy (2.26%; prevalence ratio = 2.96, CI = 2.84-3.02; compared to Army). Among foreign born, Africans were more likely to be SCT+ (prevalence ratio = 1.68, CI = 1.39-2.04; compared to non-U.S. North American).
This study estimated the prevalence of SCT within U.S. military enlisted force and describes variability across services for race, time intervals, gender, and foreign-born region and will support investigation into the health effects of SCT in young adult populations.
目前缺乏基于人群的关于美国军队中镰状细胞性状（SCT）患病率随军种和时间变化的估计数据。
利用1992年至2012年期间现役入伍人员的人口统计学、门诊和医院SCT诊疗记录（国际疾病分类第九版临床修订本282.5）数据以及有限的SCT实验室结果，按军种、种族/族裔和性别以5年时间间隔估计SCT患病率。
我们的研究共识别出15,081名SCT受试者。SCT患病率在种族、年份、性别和军种之间存在显著差异。2005 - 2009年非西班牙裔黑人的SCT患病率最高（5.02%；患病率比 = 56.33，置信区间[CI] = 52.14 - 60.85；与非西班牙裔白人相比），与1992 - 1994年相比（0.40%；患病率比 = 10.04，CI = 9.21 - 10.94），女性的患病率（2.97%；患病率比 = 3.14，CI = 3.04 - 3.25；与男性相比）以及海军的患病率（2.26%；患病率比 = 2.96，CI = 2.84 - 3.02；与陆军相比）也较高。在外国出生者中，非洲人更有可能携带SCT（患病率比 = 1.68，CI = 1.39 - 2.04；与非北美地区的美国人相比）。
本研究估计了美国军队现役入伍人员中SCT的患病率，并描述了在种族、时间间隔、性别和外国出生地区方面各军种之间的差异，这将有助于对年轻成年人群中SCT的健康影响进行调查。
