简短报告：通过总IgG和竞争性Luminex免疫测定法检测HIV感染年轻女性对四价HPV疫苗的抗体反应
Brief Report: Antibody Responses to Quadrivalent HPV Vaccination in HIV-Infected Young Women as Measured by Total IgG and Competitive Luminex Immunoassay.
作者信息
Kahn Jessica A, Xu Jiahong, Kapogiannis Bill G, Sleasman John W
机构信息
*Division of Adolescent and Transition Medicine, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH; †Westat, Rockville, MD; ‡Pediatric, Adolescent and Maternal AIDS Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Rockville, MD; and §Division of Allergy and Immunology and Division of Pulmonary and Sleep Medicine, Department of Pediatrics, Duke University School of Medicine, Durham, NC.
出版信息
J Acquir Immune Defic Syndr. 2017 Jun 1;75(2):241-245. doi: 10.1097/QAI.0000000000001355.
We compared antibody responses of HIV-infected young women to the human papillomavirus (HPV) 6, 11, 16, and 18 vaccine using total immunoglobulin (Ig) G Luminex immunoassay (LIA) and competitive Luminex immunoassay (cLIA) assays. HPV18 seropositivity after HPV vaccination as measured with IgG LIA remained high (98%) 48 weeks after vaccination, in contrast with seropositivity as measured with cLIA (73%). Seropositivity rates at week 48 as measured by both IgG LIA and cLIA remained high for HPV6, 11, and 16 (93.5%-100%). These results suggest that the lower rate of seropositivity to HPV18 when cLIA vs. IgG LIA is used is a function of the assay and does not imply lower vaccine immunogenicity.
我们使用总免疫球蛋白（Ig）G 液相芯片免疫分析（LIA）和竞争性液相芯片免疫分析（cLIA）检测，比较了感染人类免疫缺陷病毒（HIV）的年轻女性对人乳头瘤病毒（HPV）6、11、16和18型疫苗的抗体反应。接种疫苗后48周，用IgG LIA检测的HPV18血清阳性率仍保持在较高水平（98%），而用cLIA检测的血清阳性率为73%。用IgG LIA和cLIA检测的HPV6、11和16型在第48周时的血清阳性率也保持在较高水平（93.5%-100%）。这些结果表明，与IgG LIA相比，使用cLIA时HPV18血清阳性率较低是检测方法的作用，并不意味着疫苗免疫原性较低。
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