Sherwood J Matthew, Roush James K, Armbrust Laura J, Renberg Walter C
From the Department of Clinical Sciences, Kansas State University College of Veterinary Medicine, Veterinary Health Center, Manhattan, Kansas.
J Am Anim Hosp Assoc. 2017 May/Jun;53(3):135-142. doi: 10.5326/JAAHA-MS-6508. Epub 2017 Mar 14.
The objective of this study was to evaluate intra-articular dextrose prolotherapy for osteoarthritis of the elbow or stifle in dogs in a randomized, double-blind, placebo-controlled, prospective pilot study. Seventeen dogs were evaluated with 10 meeting inclusion criteria for this study. Evaluations included orthopedic exam, visual lameness scoring, Canine Brief Pain Inventory (CBPI), goniometry, kinetic gait analysis, and radiography. Initial lameness score, age, body weight, duration of lameness, and CBPI scores did not differ between groups. Change in CBPI pain severity score in the prolotherapy group from wk 6-12 was significantly less improved than in the placebo group, with no other significant differences in pain severity or pain interference scores between groups. Range of motion and radiographic scores did not differ between groups at any time. Mean kinetic forces improved in prolotherapy dogs but were not significantly different between treatment groups at any time. Although easily performed and well-tolerated, there were no statistically significant benefits of dextrose prolotherapy for treatment of osteoarthritis of the elbow and stifle in dogs. Post hoc power analysis of these sample means and standard deviations found that 29-106 animals per group would be necessary to demonstrate significant differences in kinetic forces, providing useful guidance for future studies.
本研究的目的是在一项随机、双盲、安慰剂对照的前瞻性试点研究中，评估关节内注射葡萄糖增殖疗法对犬肘部或 stifle 骨关节炎的疗效。对 17 只犬进行了评估，其中 10 只符合本研究的纳入标准。评估包括骨科检查、视觉跛行评分、犬简短疼痛量表（CBPI）、测角法、动态步态分析和放射摄影。两组之间的初始跛行评分、年龄、体重、跛行持续时间和 CBPI 评分没有差异。增殖疗法组从第 6 周 - 12 周的 CBPI 疼痛严重程度评分变化比安慰剂组改善得明显更少，两组之间在疼痛严重程度或疼痛干扰评分方面没有其他显著差异。两组在任何时候的活动范围和放射学评分都没有差异。增殖疗法组犬的平均动力学力量有所改善，但在任何时候治疗组之间均无显著差异。尽管葡萄糖增殖疗法操作简便且耐受性良好，但对于治疗犬肘部和 stifle 骨关节炎并没有统计学上的显著益处。对这些样本均值和标准差进行事后功效分析发现，每组需要 29 - 106 只动物才能证明动力学力量存在显著差异，为未来的研究提供了有用的指导。
