使用液氮处理的自体移植骨对患有口腔肿瘤的犬进行下颌骨重建。

Mandibular Reconstruction by Using a Liquid Nitrogen-Treated Autograft in a Dog with an Oral Tumor.

作者信息

Okamura Yasuhiko, Heishima Kazuki, Motegi Tomoki, Sasaki Jun, Goryo Masanobu, Nishida Hideji, Tsuchiya Hiroyuki, Katayama Masaaki, Uzuka Yuji

机构信息

From the Cooperative Department of Veterinary Medicine, Faculty of agriculture, Iwate University, Morioka, Japan (Y.O., J.S., M.G., M.K., Y.U.); the United Graduate School of Veterinary Sciences, Gifu University, Gifu, Japan (K.H.); Department of Veterinary Medicine, Faculty of Agriculture, University of Tokyo, Tokyo, Japan (T.M.); and the Department of Orthopaedic Surgery and Graduate School of Medical Science, Kanazawa University, Kanazawa, Japan (H.N., H.T.).

出版信息

J Am Anim Hosp Assoc. 2017 May/Jun;53(3):167-171. doi: 10.5326/JAAHA-MS-6339. Epub 2017 Mar 14.

DOI:10.5326/JAAHA-MS-6339

PMID:28291396

Abstract

A 10 yr old intact female German shepherd dog presented with a large peripheral odontogenic fibroma and malignant melanoma on her lower jaw. The tumor was resected with a unilateral subtotal rostral hemimandibulectomy. After the mandible was removed, it was devitalized intraoperatively by freezing it in liquid nitrogen. It was subsequently reimplanted. New bone tissue formed in the gap between the frozen bone and the host bone. The regenerated bone contained osteocytes, osteoblasts, and blood vessels. The cosmetic appearance of the dog was preserved. The dog had normal mastication. The malignant melanoma recurred rostral of the left canine tooth at 159 days after the reconstruction surgery. A subtotal hemimandibulectomy was consequently performed. This is the first reported case of mandibular reconstruction using a liquid nitrogen-treated autograft in a dog with oral tumors.

摘要

一只10岁未绝育的雌性德国牧羊犬，下颌出现一个大型外周牙源性纤维瘤和恶性黑色素瘤。通过单侧吻侧半下颌骨次全切除术切除肿瘤。下颌骨切除后，术中将其置于液氮中冷冻使其失去活力，随后进行再植。在冷冻骨与宿主骨之间的间隙形成了新的骨组织。再生骨含有骨细胞、成骨细胞和血管。该犬的外观得以保留，咀嚼功能正常。重建手术后159天，恶性黑色素瘤在左犬齿前方复发，因此进行了半下颌骨次全切除术。这是首例报道的在患有口腔肿瘤的犬中使用液氮处理的自体移植进行下颌骨重建的病例。