Koçkara Nizamettin, Sofu Hakan, Issin Ahmet, Çetinkaya Mehmet, Tayfur Mahir, Süleyman Bahadır
Department of Orthopedics and Traumatology, Medical Faculty of Erzincan University, 24100 Erzincan, Turkey.
Eklem Hastalik Cerrahisi. 2017 Apr;28(1):19-24. doi: 10.5606/ehc.2017.50897.
This study aims to assess the radiographic, histological, and biomechanical effects of pregabalin on fracture healing in a rat model of femur fracture.
A total of 32 female Wistar-Albino rats (mean age 12±1 weeks; mean body weight 236±12 grams) were randomized into four groups with eight rats in each group. Groups A and B were the control groups whereas C and D were the treatment groups. Drugs were delivered by oral gavage. Radiographic, histological and biomechanical evaluations were performed after sacrificing the rats in groups A and C on 15th postoperative day and the rats in groups B and D on 30th postoperative day.
Although radiographic results were better in groups A and B than groups C and D at the end of 15th day, no significant difference was detected at the end of 30th day. No statistically significant differences were observed between the groups on 15th and 30th days in terms of histological or biomechanical evaluation.
Administration of pregabalin did not affect fracture healing process adversely in rats.
本研究旨在评估普瑞巴林对大鼠股骨骨折模型骨折愈合的影像学、组织学和生物力学影响。
总共32只雌性Wistar白化大鼠（平均年龄12±1周；平均体重236±12克）被随机分为四组，每组8只大鼠。A组和B组为对照组，而C组和D组为治疗组。通过灌胃给药。在术后第15天处死A组和C组大鼠，术后第30天处死B组和D组大鼠后进行影像学、组织学和生物力学评估。
虽然在第15天结束时，A组和B组的影像学结果比C组和D组更好，但在第30天结束时未检测到显著差异。在第15天和第30天，各组在组织学或生物力学评估方面未观察到统计学上的显著差异。
在大鼠中，给予普瑞巴林不会对骨折愈合过程产生不利影响。
