Afşin State Hospital, Kahramanmaraş, Turkey.
Department of Orthopedics and Traumatology, Faculty of Medicine, Trakya University, Balkan Yerleşkesi, 22030, Edirne, Turkey.
Eur Spine J. 2020 Feb;29(2):332-339. doi: 10.1007/s00586-019-06226-4. Epub 2019 Nov 19.
Gamma-aminobutyric acid analogues are commonly used to treat neuropathic and chronic pain before and after spinal surgery in recent years. Aim of this study is to investigate the influence of pregabalin on spinal fusion and to determine the proper pregabalin dose for postoperative utilization in a validated rat intertransverse spinal fusion.
Lumbar intertransverse fusion surgeries performed in four groups of rats according to a previously established rat model for posterolateral spinal fusion. All rats were followed up for 6 weeks at the postoperative period by administering oral pregabalin doses of 10 (D10), 30 (D30) and 100 mg/kg/day (D100) except the control group. All rats were killed after 6 weeks and evaluated in terms of manual palpation, radiographic investigation and histological analysis to investigate posterolateral fusion.
Assessment of fusion with manual palpation revealed lower fusion rates in D100 group. In histological analysis, scores were significantly lower in D30 and D100 groups compared to the control group; this finding was interpreted as inhibition of spinal fusion. Radiographic evaluation did not reveal any significant statistical difference between groups.
Histological analysis and manual palpation results showed inhibition of spinal fusion formation with high doses of pregabalin. According to these results, administration of high-dose pregabalin should be avoided at the postoperative period until successful fusion is obtained in patients who undergo spinal fusion surgery. These slides can be retrieved under electronic supplementary material.
近年来，γ-氨基丁酸类似物常用于脊柱手术前后治疗神经性和慢性疼痛。本研究旨在探讨普瑞巴林对脊柱融合的影响，并确定在经过验证的大鼠横突间脊柱融合模型中术后应用的合适普瑞巴林剂量。
根据先前建立的大鼠后路脊柱融合模型，对四组大鼠进行腰椎横突间融合手术。在术后期间，所有大鼠均以 10（D10）、30（D30）和 100mg/kg/天（D100）的口服普瑞巴林剂量进行治疗，除对照组外。所有大鼠在 6 周后被处死，并通过手动触诊、影像学研究和组织学分析进行评估，以研究后路融合。
手动触诊评估融合显示 D100 组融合率较低。在组织学分析中，D30 和 D100 组的评分明显低于对照组；这一发现被解释为抑制脊柱融合。影像学评估未显示组间存在任何显著统计学差异。
组织学分析和手动触诊结果显示高剂量普瑞巴林抑制脊柱融合形成。根据这些结果，在脊柱融合手术患者获得成功融合之前，应避免在术后期间给予高剂量普瑞巴林。这些幻灯片可在电子补充材料中检索到。
