急性病毒性脑炎期间神经炎症和损伤的分子机制
Molecular mechanisms of neuroinflammation and injury during acute viral encephalitis.
作者信息
Shives Katherine D, Tyler Kenneth L, Beckham J David
机构信息
Department of Immunology and Microbiology, University of Colorado School of Medicine, USA.
Department of Immunology and Microbiology, University of Colorado School of Medicine, USA; Department of Neurology, University of Colorado School of Medicine, USA; Department of Medicine, Division of Infection Diseases, USA.
出版信息
J Neuroimmunol. 2017 Jul 15;308:102-111. doi: 10.1016/j.jneuroim.2017.03.006. Epub 2017 Mar 11.
Abstract
Viral infections in the central nervous system are a major cause of encephalitis. West Nile virus (WNV) and Herpes simplex virus (HSV) are the most common causes of viral encephalitis in the United States. We review the role of neuroinflammation in the pathogenesis of WNV and HSV infections in the central nervous system (CNS). We discuss the role of the innate and cell-mediated immune responses in peripheral control of viral infection, viral invasion of the CNS, and in inflammatory-mediated neuronal injury. By understanding the role of specific inflammatory responses to viral infections in the CNS, targeted therapeutic approaches can be developed to maximize control of acute viral infection while minimizing neuronal injury in the CNS.
摘要
中枢神经系统的病毒感染是脑炎的主要病因。西尼罗河病毒（WNV）和单纯疱疹病毒（HSV）是美国病毒性脑炎最常见的病因。我们综述了神经炎症在西尼罗河病毒和单纯疱疹病毒中枢神经系统（CNS）感染发病机制中的作用。我们讨论了固有免疫和细胞介导的免疫反应在病毒感染的外周控制、病毒侵入中枢神经系统以及炎症介导的神经元损伤中的作用。通过了解中枢神经系统中针对病毒感染的特定炎症反应的作用，可以开发出有针对性的治疗方法，以最大程度地控制急性病毒感染，同时最小化中枢神经系统中的神经元损伤。
相似文献
1
Molecular mechanisms of neuroinflammation and injury during acute viral encephalitis.急性病毒性脑炎期间神经炎症和损伤的分子机制
J Neuroimmunol. 2017 Jul 15;308:102-111. doi: 10.1016/j.jneuroim.2017.03.006. Epub 2017 Mar 11.
2
West Nile Virus spread and differential chemokine response in the central nervous system of mice: Role in pathogenic mechanisms of encephalitis.西尼罗河病毒在小鼠中枢神经系统中的传播和差异趋化因子反应：在脑炎发病机制中的作用。
Transbound Emerg Dis. 2020 Mar;67(2):799-810. doi: 10.1111/tbed.13401. Epub 2019 Nov 15.
3
Innate Immune Signaling and Role of Glial Cells in Herpes Simplex Virus- and Rabies Virus-Induced Encephalitis.先天免疫信号和神经胶质细胞在单纯疱疹病毒和狂犬病病毒诱导的脑炎中的作用。
Viruses. 2021 Nov 25;13(12):2364. doi: 10.3390/v13122364.
4
Intrinsic Innate Immune Responses Control Viral Growth and Protect against Neuronal Death in an Model of West Nile Virus-Induced Central Nervous System Disease.内在先天免疫反应控制病毒生长并防止西尼罗河病毒诱导的中枢神经系统疾病模型中的神经元死亡。
J Virol. 2021 Aug 25;95(18):e0083521. doi: 10.1128/JVI.00835-21.
5
STING is required for host defense against neuropathological West Nile virus infection.STING 对于宿主防御神经病理性西尼罗河病毒感染是必需的。
PLoS Pathog. 2019 Aug 15;15(8):e1007899. doi: 10.1371/journal.ppat.1007899. eCollection 2019 Aug.
6
Immune responses to West Nile virus infection in the central nervous system.西尼罗河病毒感染在中枢神经系统中的免疫反应。
Viruses. 2012 Dec 17;4(12):3812-30. doi: 10.3390/v4123812.
7
Chemokine Receptor Ccr7 Restricts Fatal West Nile Virus Encephalitis.趋化因子受体Ccr7可限制致命性西尼罗河病毒脑炎。
J Virol. 2017 Apr 28;91(10). doi: 10.1128/JVI.02409-16. Print 2017 May 15.
8
IL-1β signaling promotes CNS-intrinsic immune control of West Nile virus infection.IL-1β 信号促进中枢神经系统固有免疫对西尼罗河病毒感染的控制。
PLoS Pathog. 2012;8(11):e1003039. doi: 10.1371/journal.ppat.1003039. Epub 2012 Nov 29.
9
Genetic diversity in the collaborative cross model recapitulates human West Nile virus disease outcomes.协作杂交模型中的遗传多样性概括了人类西尼罗河病毒病的发病情况。
mBio. 2015 May 5;6(3):e00493-15. doi: 10.1128/mBio.00493-15.
10
Caspase 3-dependent cell death of neurons contributes to the pathogenesis of West Nile virus encephalitis.半胱天冬酶3依赖性神经元细胞死亡促成西尼罗河病毒脑炎的发病机制。
J Virol. 2007 Mar;81(6):2614-23. doi: 10.1128/JVI.02311-06. Epub 2006 Dec 27.
引用本文的文献
1
Development of a prediction model integrating PD-1 and ICOS for early differential diagnosis between autoimmune and viral encephalitis.整合PD-1和ICOS的预测模型用于自身免疫性脑炎与病毒性脑炎早期鉴别诊断的研究
Front Immunol. 2025 Apr 25;16:1550963. doi: 10.3389/fimmu.2025.1550963. eCollection 2025.
2
Targeting SARM1 as a novel neuroprotective therapy in neurotropic viral infections.将SARM1作为嗜神经病毒感染的新型神经保护疗法的靶点。
J Neuroinflammation. 2025 Apr 20;22(1):113. doi: 10.1186/s12974-025-03423-5.
3
CNS Viral Infections-What to Consider for Improving Drug Treatment: A Plea for Using Mathematical Modeling Approaches.中枢神经系统病毒感染——改善药物治疗需要考虑的因素：呼吁采用数学建模方法。
CNS Drugs. 2024 May;38(5):349-373. doi: 10.1007/s40263-024-01082-3. Epub 2024 Apr 5.
4
Herpes simplex virus infection induces necroptosis of neurons and astrocytes in human fetal organotypic brain slice cultures.单纯疱疹病毒感染诱导人胎脑器官型脑片培养中神经元和星形胶质细胞的坏死性凋亡。
J Neuroinflammation. 2024 Feb 1;21(1):38. doi: 10.1186/s12974-024-03027-5.
5
Neuroinvasive Flavivirus Pathogenesis Is Restricted by Host Genetic Factors in Collaborative Cross Mice, Independently of .神经侵袭性黄病毒发病机制受协作交叉小鼠宿主遗传因素的限制，与......无关。
J Virol. 2023 Jul 27;97(7):e0071523. doi: 10.1128/jvi.00715-23. Epub 2023 Jun 13.
6
Steroids for the treatment of viral encephalitis: a systematic literature review and meta-analysis.类固醇治疗病毒性脑炎：系统文献回顾和荟萃分析。
J Neurol. 2023 Jul;270(7):3603-3615. doi: 10.1007/s00415-023-11715-0. Epub 2023 Apr 15.
7
SARS-CoV-2 Spike protein induces TLR4-mediated long-term cognitive dysfunction recapitulating post-COVID-19 syndrome in mice.SARS-CoV-2 刺突蛋白诱导 TLR4 介导的长期认知功能障碍，重现 COVID-19 后综合征在小鼠模型中的表现。
Cell Rep. 2023 Mar 28;42(3):112189. doi: 10.1016/j.celrep.2023.112189. Epub 2023 Feb 17.
8
Acute neurologic emerging flaviviruses.急性神经系统新发黄病毒
Ther Adv Infect Dis. 2022 Jun 13;9:20499361221102664. doi: 10.1177/20499361221102664. eCollection 2022 Jan-Dec.
9
Role of Dendritic Cells in Viral Brain Infections.树突状细胞在病毒脑感染中的作用。
Front Immunol. 2022 Apr 22;13:862053. doi: 10.3389/fimmu.2022.862053. eCollection 2022.
10
Viral Encephalitis in Adults: A Narrative Review.成人病毒性脑炎：叙述性综述。
Rev Recent Clin Trials. 2022;17(4):259-267. doi: 10.2174/1574887116666211118141117.
本文引用的文献
1
Zika virus produces noncoding RNAs using a multi-pseudoknot structure that confounds a cellular exonuclease.寨卡病毒利用一种能使细胞外切核酸酶失效的多假结结构来产生非编码RNA。
Science. 2016 Dec 2;354(6316):1148-1152. doi: 10.1126/science.aah3963. Epub 2016 Nov 10.
2
West Nile Virus Population Structure, Injury, and Interferon-Stimulated Gene Expression in the Brain From a Fatal Case of Encephalitis.西尼罗河病毒在致命脑炎病例中的种群结构、损伤和干扰素刺激基因表达。
Open Forum Infect Dis. 2015 Nov 20;3(1):ofv182. doi: 10.1093/ofid/ofv182. eCollection 2016 Jan.
3
Alpha-Synuclein Expression Restricts RNA Viral Infections in the Brain.α-突触核蛋白的表达限制大脑中的RNA病毒感染。
J Virol. 2015 Dec 30;90(6):2767-82. doi: 10.1128/JVI.02949-15.
4
The Interferon-Stimulated Gene Ifi27l2a Restricts West Nile Virus Infection and Pathogenesis in a Cell-Type- and Region-Specific Manner.干扰素刺激基因Ifi27l2a以细胞类型和区域特异性方式限制西尼罗河病毒感染和发病机制。
J Virol. 2015 Dec 23;90(5):2600-15. doi: 10.1128/JVI.02463-15.
5
CCR5 limits cortical viral loads during West Nile virus infection of the central nervous system.在西尼罗河病毒感染中枢神经系统期间，CCR5限制皮质病毒载量。
J Neuroinflammation. 2015 Dec 15;12:233. doi: 10.1186/s12974-015-0447-9.
6
Induction of virus-specific effector immune cell response limits virus replication and severe disease in mice infected with non-lethal West Nile virus Eg101 strain.诱导病毒特异性效应免疫细胞应答可限制感染非致死性西尼罗河病毒 Eg101 株的小鼠中的病毒复制和严重疾病。
J Neuroinflammation. 2015 Sep 22;12:178. doi: 10.1186/s12974-015-0400-y.
7
Long-term outcome of severe herpes simplex encephalitis: a population-based observational study.严重单纯疱疹病毒性脑炎的长期预后：一项基于人群的观察性研究。
Crit Care. 2015 Sep 21;19(1):345. doi: 10.1186/s13054-015-1046-y.
8
Functional IRF3 deficiency in a patient with herpes simplex encephalitis.一名单纯疱疹性脑炎患者存在功能性IRF3缺陷。
J Exp Med. 2015 Aug 24;212(9):1371-9. doi: 10.1084/jem.20142274. Epub 2015 Jul 27.
9
Innate immune response during herpes simplex virus encephalitis and development of immunomodulatory strategies.单纯疱疹病毒性脑炎期间的固有免疫应答与免疫调节策略的制定。
Rev Med Virol. 2015 Sep;25(5):300-19. doi: 10.1002/rmv.1848. Epub 2015 Jul 23.
10
Neuronal Interferon Signaling Is Required for Protection against Herpes Simplex Virus Replication and Pathogenesis.神经元干扰素信号传导是抵御单纯疱疹病毒复制和发病机制所必需的。
PLoS Pathog. 2015 Jul 8;11(7):e1005028. doi: 10.1371/journal.ppat.1005028. eCollection 2015 Jul.
Zotero 插件