白细胞介素-17A在肾脏疾病发病机制中的作用。

The role of interleukin-17A in the pathogenesis of kidney diseases.

作者信息

Cortvrindt Charlotte, Speeckaert Reinhart, Moerman Alena, Delanghe Joris R, Speeckaert Marijn M

机构信息

Department of Nephrology, Ghent University Hospital, Ghent, Belgium.

Department of Dermatology, Ghent University Hospital, Ghent, Belgium.

出版信息

Pathology. 2017 Apr;49(3):247-258. doi: 10.1016/j.pathol.2017.01.003. Epub 2017 Mar 11.

DOI:10.1016/j.pathol.2017.01.003

PMID:28291548

Abstract

Being a member of the IL-17 family, comprising six structurally related ligands, IL-17A is a cytokine, produced by multiple cell types, such as CD4αβ T cells, γδ T cells, natural killer cells, neutrophils, macrophages, dendritic cells, lymphoid tissue inducer cells, mast cells and plasma cells. IL-17A participates in tissue inflammation by inducing the expression of chemokines, proinflammatory cytokines and matrix metalloproteases. Besides its role in host defence against infectious diseases, IL-17A is involved in different autoimmune and inflammatory diseases. In this review, we will highlight the role of IL-17A in the pathogenesis of acute and chronic kidney diseases. Due to its pleiotropic character, IL-17A is involved in the development of atherosclerosis, hypertension, diabetic nephropathy, ischaemia-reperfusion injury, fibrosis, glomerulonephritis, nephrotic syndrome, minimal change disease and acute renal allograft rejection. In addition, inhibition of IL-17A may be a promising therapeutic target to prevent end-stage renal disease.

摘要

作为白细胞介素-17（IL-17）家族的一员（该家族由六种结构相关的配体组成），IL-17A是一种细胞因子，由多种细胞类型产生，如CD4αβT细胞、γδT细胞、自然杀伤细胞、中性粒细胞、巨噬细胞、树突状细胞、淋巴组织诱导细胞、肥大细胞和浆细胞。IL-17A通过诱导趋化因子、促炎细胞因子和基质金属蛋白酶的表达参与组织炎症。除了在宿主抵御传染病中发挥作用外，IL-17A还参与不同的自身免疫性疾病和炎症性疾病。在本综述中，我们将重点阐述IL-17A在急性和慢性肾脏疾病发病机制中的作用。由于其多效性，IL-17A参与动脉粥样硬化、高血压、糖尿病肾病、缺血再灌注损伤、纤维化、肾小球肾炎、肾病综合征、微小病变病和急性肾移植排斥反应的发生发展。此外，抑制IL-17A可能是预防终末期肾病的一个有前景的治疗靶点。