Nowowiejska Julia, Baran Anna, Hermanowicz Justyna Magdalena, Sieklucka Beata, Koper-Lenkiewicz Olga Martyna, Kamińska Joanna, Pawlak Krystyna, Pawlak Dariusz, Flisiak Iwona
Department of Dermatology and Venereology, Medical University of Bialystok, Bialystok, Poland.
Department of Pharmacodynamics, Medical University of Bialystok, Bialystok, Poland.
Psoriasis (Auckl). 2025 Jul 18;15:285-299. doi: 10.2147/PTT.S530313. eCollection 2025.
There is a dispute as to whether patients with psoriasis have impaired kidney function. We aimed to assess several recognized and experimental markers of glomerular filtration and tubular function in such patients to find out whether they have decreased kidney function.
The study involved 60 patients with psoriasis and 30 volunteers without dermatoses. The following molecules were analyzed by ELISA: serum creatinine, cystatin C, beta-trace protein, albumins, uromodulin; urinary albumins, cystatin C, alpha-1-microglobulin, beta-2-microglobulin, uromodulin, klotho, and fatty acid-binding protein 1, and nephrin.
The following absolute values of markers concentrations were measured in patients, respectively: serum-1.13 (0.6-1.9)mg/dl, 4.511 (2.356-10.31)mg/l, 19.8 (2.8-48)ng/mL, 4.2 (1.9-8.85)g/dl, 212.3 (32.35-583.9)ng/mL, urine-5 (3-39)g/dl, 24096 (79.94-99020)ng/mL, 0.9342 (0.2088-6.213)ng/mL, 22.65 (0.85-105.8)ng/mL, 6.388 (0.8960-15.94)ng/mL, 0.08 (0.002-0.387)ng/mL, 1.773 (1.706-2.146)ng/mL, 0.128 (0.095-0.298)ng/mL. The patients had significantly lower serum albumin concentration (p<0.001) and higher urinary albumin (p<0.05), significantly higher serum cystatin C (p<0.01), and absolute urinary nephrin (p<0.05). There was no difference between patients and controls in terms of serum creatinine or beta trace protein concentration (p>0.05). There were no significant differences in the concentration of the tubular markers (urinary cystatin C, alpha-1-microglobulin, beta-2-microglobulin, klotho, and fatty acid-binding protein 1) between patients and controls, except for serum and urinary uromodulin, which were significantly lower in patients (p<0.01, p<0.001, respectively). We found no significant correlations between the investigated markers' concentration and clinical or demographic parameters (p>0.05).
Despite the differences between patients and controls in terms of glomerular filtration markers, the median values of markers' concentration were within normal limits. Based on the assessment of the markers, it does not seem that impaired glomerular and tubular function occurs more frequently in patients with psoriasis. Nevertheless, due to the higher prevalence of diabetes mellitus and arterial hypertension in psoriatics and nephrotoxic properties of antipsoriatic drugs - caution must be exercised and easy screening tools should be considered.
银屑病患者的肾功能是否受损存在争议。我们旨在评估此类患者肾小球滤过和肾小管功能的几种公认及实验性标志物，以确定他们的肾功能是否下降。
该研究纳入了60例银屑病患者和30例无皮肤病的志愿者。通过酶联免疫吸附测定法（ELISA）分析了以下分子：血清肌酐、胱抑素C、β-微量蛋白、白蛋白、尿调节蛋白；尿白蛋白、胱抑素C、α-1-微球蛋白、β-2-微球蛋白、尿调节蛋白、klotho和脂肪酸结合蛋白1以及nephrin。
分别测定了患者标志物浓度的以下绝对值：血清 - 1.13（0.6 - 1.9）mg/dl、4.511（2.356 - 10.31）mg/l、19.8（2.8 - 48）ng/mL、4.2（1.9 - 8.85）g/dl、212.3（32.35 - 583.9）ng/mL，尿液 - 5（3 - 39）g/dl、24096（79.94 - 99020）ng/mL、0.9342（0.2088 - 6.213）ng/mL、22.65（0.85 - 105.8）ng/mL、6.388（0.8960 - 15.94）ng/mL、0.08（0.002 - 0.387）ng/mL、1.773（1.706 - 2.146）ng/mL、0.128（0.095 - 0.298）ng/mL。患者的血清白蛋白浓度显著降低（p<0.001），尿白蛋白升高（p<0.05），血清胱抑素C显著升高（p<0.01），尿nephrin绝对值升高（p<0.05）。患者与对照组在血清肌酐或β-微量蛋白浓度方面无差异（p>0.05）。患者与对照组之间肾小管标志物（尿胱抑素C、α-1-微球蛋白、β-2-微球蛋白、klotho和脂肪酸结合蛋白1）的浓度无显著差异，但血清和尿尿调节蛋白除外，患者的血清和尿尿调节蛋白显著降低（分别为p<0.01，p<0.001）。我们发现所研究的标志物浓度与临床或人口统计学参数之间无显著相关性（p>
