[原发性上皮样肾上腺血管肉瘤酷似未分化癌]

[Primary epithelioid adrenal angiosarcoma mimicking undifferentiated carcinoma].

作者信息

Miladi Samira, Harrar Yaëlle, Battistella Maxime, Bertheau Philippe, Meignin Véronique, Roche Brigitte, Bouhidel Fatiha Amira

机构信息

Service de pathologie, hôpital Saint-Louis, AP-HP, 1, avenue Claude-Vellefaux, 75475 Paris cedex 10, France.

Service de pathologie, hôpital Saint-Louis, AP-HP, 1, avenue Claude-Vellefaux, 75475 Paris cedex 10, France; Université Paris-Diderot, 10, rue Françoise-Dolto, 75205 Paris cedex 13, France; Inserm UMR-S-1165, 1, avenue Claude-Vellefaux, 75475 Paris cedex 10, France.

出版信息

Ann Pathol. 2017 Apr;37(2):162-165. doi: 10.1016/j.annpat.2016.10.002. Epub 2017 Mar 11.

DOI:10.1016/j.annpat.2016.10.002

PMID:28291558

Abstract

The adrenal primary epithelioid angiosarcoma (ASE) is a rare malignant tumor which can be histologically confused with other neoplasms. We report one case in a 79-year-old man who underwent adrenal tumor surgery for a mass fortuitly discovered by imaging for examination of an inflammatory syndrome associated with anemia. The histological diagnosis was difficult because of the undifferentiated and epithelioid appearance of tumor cells, whose immunohistochemical epithelial markers positivity led to frequent confusion with a metastatic carcinoma. Careful research for vascular differentiation at histopathological study and expression of immunohistochimical endothelial markers, are crucial to confirm the diagnosis.

摘要

肾上腺原发性上皮样血管肉瘤（ASE）是一种罕见的恶性肿瘤，在组织学上可能与其他肿瘤混淆。我们报告一例79岁男性病例，该患者因与贫血相关的炎症综合征成像检查偶然发现肿块而接受肾上腺肿瘤手术。由于肿瘤细胞的未分化和上皮样外观，组织学诊断困难，其免疫组化上皮标志物阳性常导致与转移性癌混淆。在组织病理学研究中仔细研究血管分化以及免疫组化内皮标志物的表达，对于确诊至关重要。