Takizawa Katsumi, Kohashi Kenichi, Negishi Takahito, Taguchi Kenichi, Yamada Yuichi, Nakamura Motonobu, Oda Yoshinao
Department of Pathology, National Kyushu Cancer Center, Fukuoka, 811-1395, Japan.
Department of Anatomic pathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, 812-8582, Japan.
Pathol Res Pract. 2017 Jun;213(6):702-705. doi: 10.1016/j.prp.2017.04.017. Epub 2017 Apr 19.
Primary adrenal angiosarcoma is an extremely rare vascular tumor. We report a case of a 63-year-old man with a collision tumor of epithelioid angiosarcoma and adrenocortical adenoma of the right adrenal gland. The adrenal tumor was incidentally observed by a preoperative computed tomography (CT) scan of penis squamous cell carcinoma. The patient underwent a right laparoscopic adrenalectomy, and the tumor size measured 34×34×15mm. Histological examination revealed two different tumor cell proliferations, namely epithelioid angiosarcoma and adrenocortical adenoma. He had no symptoms or abnormality in his endocrine studies, so the adrenocortical adenoma was considered non-functioning. Three months after the adrenalectomy, bilateral pleural metastasis was observed by CT scan and pleural biopsy. Paclitaxel monotherapy was performed, and the tumor retreated. The patient died one and a half years after the adrenalectomy, but the cause of death was believed to be another disease (metastatic penis squamous cell carcinoma). To the best of our knowledge, this is the fourth report of primary adrenal angiosarcoma combined with adrenocortical adenoma.
原发性肾上腺血管肉瘤是一种极其罕见的血管肿瘤。我们报告一例63岁男性患者，其右侧肾上腺存在上皮样血管肉瘤与肾上腺皮质腺瘤的碰撞瘤。该肾上腺肿瘤是在对阴茎鳞状细胞癌进行术前计算机断层扫描（CT）时偶然发现的。患者接受了右侧腹腔镜肾上腺切除术，肿瘤大小为34×34×15mm。组织学检查显示有两种不同的肿瘤细胞增殖，即上皮样血管肉瘤和肾上腺皮质腺瘤。他没有症状，内分泌检查也无异常，因此肾上腺皮质腺瘤被认为是无功能的。肾上腺切除术后三个月，CT扫描及胸膜活检发现双侧胸膜转移。进行了紫杉醇单药治疗，肿瘤缩小。患者在肾上腺切除术后一年半死亡，但死亡原因被认为是另一种疾病（转移性阴茎鳞状细胞癌）。据我们所知，这是原发性肾上腺血管肉瘤合并肾上腺皮质腺瘤的第四例报告。
