Graduate Institute of Clinical Dentistry, School of Dentistry, National Taiwan University, Taipei, Taiwan; Department of Dentistry, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan.
Graduate Institute of Clinical Dentistry, School of Dentistry, National Taiwan University, Taipei, Taiwan; Department of Dentistry, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan; Graduate Institute of Oral Biology, School of Dentistry, National Taiwan University, Taipei, Taiwan.
J Formos Med Assoc. 2017 Jul;116(7):505-511. doi: 10.1016/j.jfma.2017.02.005. Epub 2017 Mar 11.
BACKGROUND/PURPOSE: Patients with microcytosis (defined as mean corpuscular volume < 80 fL) are not uncommonly found in oral mucosal disease clinics. This study assessed the anemia statuses and hematinic deficiencies in 240 oral mucosal disease patients with microcytosis.
The mean red blood cell (RBC) count, mean corpuscular volume, and RBC distribution width, as well as blood concentrations of hemoglobin (Hb), iron, vitamin B12, folic acid, and homocysteine in 240 microcytosis patients and in 240 age- and sex-matched healthy control individuals were measured and compared.
Microcytosis patients had significantly lower mean Hb, iron, and folic acid levels as well as significantly higher mean RBC count and RBC distribution width than healthy control individuals. Microcytosis patients also had significantly greater frequencies of Hb, iron, vitamin B12, and folic acid deficiencies as well as of RBC number > 5 × 10/L, and abnormally high homocysteine levels than healthy control individuals. Moreover, 162 (67.5%) of the 240 microcytosis patients had anemia. Of 162 anemic microcytosis patients, 87 (53.7%) had iron deficiency anemia, 61 (37.7%) had thalassemia trait (TT)-induced anemia, and 14 (8.6%) had other microcytic anemia.
We conclude that approximately 45%, 4%, and 5% of microcytosis patients have iron, vitamin B12, and folic acid deficiencies, respectively, and approximately 10% of microcytosis patients have abnormally high homocysteine levels. Moreover, 67.5% of 240 microcytosis patients and 50.8% of 120 TT patients had anemia. Iron deficiency anemia is the most common type of anemia in microcytosis patients, followed by TT-induced anemia and other microcytic anemia.
背景/目的：在口腔黏膜病门诊中，经常会发现小红细胞症（定义为平均红细胞体积＜80fl）患者。本研究评估了 240 例口腔黏膜病小红细胞症患者的贫血状态和血液学缺乏情况。
测量并比较了 240 例小红细胞症患者和 240 例年龄和性别匹配的健康对照者的平均红细胞（RBC）计数、平均红细胞体积和 RBC 分布宽度，以及血红蛋白（Hb）、铁、维生素 B12、叶酸和同型半胱氨酸的血液浓度。
与健康对照组相比，小红细胞症患者的平均 Hb、铁和叶酸水平显著降低，RBC 计数和 RBC 分布宽度显著升高。小红细胞症患者的 Hb、铁、维生素 B12 和叶酸缺乏以及 RBC 数量＞5×10/L 和异常高的同型半胱氨酸水平的频率也显著高于健康对照组。此外，240 例小红细胞症患者中 162 例（67.5%）患有贫血。在 162 例贫血性小红细胞症患者中，87 例（53.7%）为缺铁性贫血，61 例（37.7%）为地中海贫血特征性贫血，14 例（8.6%）为其他小细胞性贫血。
我们得出结论，大约 45%、4%和 5%的小红细胞症患者分别有铁、维生素 B12 和叶酸缺乏症，大约 10%的小红细胞症患者有异常高的同型半胱氨酸水平。此外，240 例小红细胞症患者中有 67.5%，120 例 TT 患者中有 50.8%患有贫血。缺铁性贫血是小红细胞症患者最常见的贫血类型，其次是 TT 诱导的贫血和其他小细胞性贫血。
