胃壁细胞抗体阳性和阴性萎缩性舌炎患者的贫血、血液营养素缺乏和高同型半胱氨酸血症。
Anemia, hematinic deficiencies, and hyperhomocysteinemia in gastric parietal cell antibody-positive and -negative atrophic glossitis patients.
机构信息
Department of Dentistry, Far Eastern Memorial Hospital, New Taipei City, Taiwan; Graduate Institute of Clinical Dentistry, School of Dentistry, National Taiwan University, Taipei, Taiwan; Department of Dentistry, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan; Graduate Institute of Oral Biology, School of Dentistry, National Taiwan University, Taipei, Taiwan.
Graduate Institute of Clinical Dentistry, School of Dentistry, National Taiwan University, Taipei, Taiwan; Department of Dentistry, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan; Graduate Institute of Oral Biology, School of Dentistry, National Taiwan University, Taipei, Taiwan.
出版信息
J Formos Med Assoc. 2019 Feb;118(2):565-571. doi: 10.1016/j.jfma.2018.12.005. Epub 2018 Dec 21.
BACKGROUND/PURPOSE: Approximately 27% of atrophic glossitis (AG) patients have the serum gastric parietal cell antibody (GPCA) positivity. This study assessed whether the serum GPCA or AG itself was a significant factor causing anemia, hematinic deficiencies, and hyperhomocysteinemia in GPCA-positive AG (GPCAAG) and GPCA-negative AG (GPCAAG) patients.
METHODS
The mean corpuscular volume (MCV) and mean blood hemoglobin (Hb), iron, vitamin B12, folic acid, and homocysteine levels were measured and compared between any two of three groups of 284 GPCAAG, 780 GPCAAG patients, and 532 healthy control subjects.
RESULTS
Both 284 GPCAAG and 780 GPCAAG patients had significantly higher frequencies of microcytosis, macrocytosis, blood Hb, iron, vitamin B12, and folic acid deficiencies, and hyperhomocysteinemia than 532 healthy control subjects. Moreover, 284 GPCAAG patients had significantly higher frequencies of macrocytosis, vitamin B12 deficiency, and hyperhomocysteinemia than 780 GPCAAG patients. Sixty-three (22.2%) of 284 GPCAAG patients and 139 (17.8%) of 780 GPCAAG patients had anemia. The normocytic anemia (42.9%), pernicious anemia (34.9%), and iron deficiency anemia (15.9%) were the three most common types of anemia in the 63 anemic GPCAAG patients. Moreover, the normocytic anemia (64.8%), iron deficiency anemia (14.4%), and thalassemia trait-induced anemia (13.7%) were the three most common types of anemia in 139 anemic GPCAAG patients.
CONCLUSION
The disease of AG itself is a significant factor causing anemia, hematinic deficiencies, and hyperhomocysteinemia in both GPCAAG and GPCAAG patients. The serum GPCA also plays a significant role in causing macrocytosis, vitamin B12 deficiency, and hyperhomocysteinemia in GPCAAG patients.
背景/目的：大约 27%的萎缩性舌炎（AG）患者血清壁细胞抗体（GPCA）阳性。本研究评估了血清 GPCA 或 AG 本身是否是导致 GPCA 阳性 AG（GPCAAG）和 GPCA 阴性 AG（GPCAAG）患者贫血、血液营养缺乏和高同型半胱氨酸血症的重要因素。
方法
测量并比较了 284 例 GPCAAG、780 例 GPCAAG 患者和 532 例健康对照组之间任何两组的平均红细胞体积（MCV）和平均血血红蛋白（Hb）、铁、维生素 B12、叶酸和同型半胱氨酸水平。
结果
284 例 GPCAAG 和 780 例 GPCAAG 患者的小细胞、大细胞、血 Hb、铁、维生素 B12 和叶酸缺乏以及高同型半胱氨酸血症的频率均明显高于 532 例健康对照组。此外，284 例 GPCAAG 患者的大细胞、维生素 B12 缺乏和高同型半胱氨酸血症的频率明显高于 780 例 GPCAAG 患者。284 例 GPCAAG 患者中有 63 例（22.2%）和 780 例 GPCAAG 患者中有 139 例（17.8%）贫血。63 例贫血的 GPCAAG 患者中，正细胞性贫血（42.9%）、恶性贫血（34.9%）和缺铁性贫血（15.9%）是三种最常见的贫血类型。此外，在 139 例贫血的 GPCAAG 患者中，正细胞性贫血（64.8%）、缺铁性贫血（14.4%）和地中海贫血特征性贫血（13.7%）是三种最常见的贫血类型。
结论
AG 本身的疾病是导致 GPCAAG 和 GPCAAG 患者贫血、血液营养缺乏和高同型半胱氨酸血症的重要因素。血清 GPCA 也在导致 GPCAAG 患者的大细胞、维生素 B12 缺乏和高同型半胱氨酸血症中发挥重要作用。
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