Li Jinwan, Chen Xiaoli, Dai Meiyu, Huang Shifeng, Chen Jingfan, Dai Shengming
Medical Science Laboratory, the Fourth Affiliated Hospital of Guangxi Medical University, No. 1 Liushi Road, Liuzhou city, Guangxi Province 545005, China.
Medical Science Laboratory, the Fourth Affiliated Hospital of Guangxi Medical University, No. 1 Liushi Road, Liuzhou city, Guangxi Province 545005, China.
Clin Res Hepatol Gastroenterol. 2017 Oct;41(5):543-553. doi: 10.1016/j.clinre.2017.01.010. Epub 2017 Mar 11.
Osteopontin (OPN) has been reported as a potential biomarker for diagnosis of hepatocellular carcinoma (HCC) in many inconsistent results. This study demonstrates a systematic meta-analysis for the evaluation on diagnostic accuracy of serum or plasma OPN and alpha-fetoprotein (AFP) alone and combined assays for HCC.
Relevant literatures were searched in PubMed up to August 2016. The quality of each study was evaluated by QUADAS-2 (quality assessment for studies of diagnostic accuracy). Statistical analysis was performed by Meta-Disc 1.4 and Stata 12.0. The random-effect models were used to estimate pooled sensitivity, specificity and other diagnostic indicators of OPN and/or AFP in HCC.
A total of 14 case-control literatures (15 studies) met the inclusion criteria in this meta-analysis. The respective pooled diagnostic sensitivity and specificity were 0.71 (95% CI: 0.69-0.74) and 0.80 (95% CI: 0.78-0.82) for OPN; 0.61 (95% CI: 0.58-0.63) and 0.92 (95% CI: 0.91-0.94) for AFP; 0.82 (95% CI: 0.79-0.84) and 0.77 (95% CI: 0.74-0.80) for OPN plus AFP. Their area under the curve (AUC) values were 0.8786, 0.8718 and 0.9005, respectively.
Combination of OPN and AFP was better than OPN or AFP alone in diagnosis of HCC.
骨桥蛋白（OPN）已被报道为肝细胞癌（HCC）诊断的潜在生物标志物，但结果多有不一致。本研究进行了一项系统的荟萃分析，以评估血清或血浆OPN和甲胎蛋白（AFP）单独及联合检测对HCC的诊断准确性。
截至2016年8月在PubMed上检索相关文献。每项研究的质量通过QUADAS - 2（诊断准确性研究的质量评估）进行评估。采用Meta - Disc 1.4和Stata 12.0进行统计分析。随机效应模型用于估计OPN和/或AFP在HCC中的合并敏感性、特异性及其他诊断指标。
本荟萃分析共纳入14篇病例对照文献（15项研究）。OPN的合并诊断敏感性和特异性分别为0.71（95%可信区间：0.69 - 0.74）和0.80（95%可信区间：0.78 - 0.82）；AFP的分别为0.61（95%可信区间：0.58 - 0.63）和0.92（95%可信区间：0.91 - 0.94）；OPN加AFP的分别为0.82（95%可信区间：0.79 - 0.84）和0.77（95%可信区间：0.74 - 0.80）。它们的曲线下面积（AUC）值分别为0.8786、0.8718和0.9005。
在HCC诊断中，OPN与AFP联合检测优于单独检测OPN或AFP。
