Guangxi Zhuang Autonomous Region Center for Disease Prevention and Control, Guangxi Key Laboratory for the Prevention and Control of Viral Hepatitis, Nanning, China.
School of Preclinical Medicine, Guangxi Medical University, Nanning, China.
Intervirology. 2021;64(3):126-134. doi: 10.1159/000513687. Epub 2021 Mar 18.
Serum osteopontin (OPN) concentrations were found to be significantly increased in patients infected with hepatitis B virus (HBV) and patients with hepatocellular carcinoma (HCC).
The aim of this study was to determine the association among HCC, OPN, and HBV.
Two hundred and forty-one subjects were recruited and divided into 6 groups: healthy controls, asymptomatic HBsAg carriers, HBsAg (-) patients with other tumors, HBsAg (+) chronic liver disease patients, HBsAg (+) patients with HCC, and HBsAg (-) patients with HCC or liver cirrhosis (LC). Serum concentrations of OPN and HBsAg were measured and analyzed.
OPN concentrations in the HBsAg (+) HCC group were significantly higher than the healthy control group and the HBsAg (-) patients with other cancers (both p = 0.0001). The OPN concentrations of the HBsAg (-) patients with HCC or LC also did not differ significantly from those of the healthy control group (p = 0.075). There is a correlation between the titer of HBsAg and concentrations of OPN in all 3 HBsAg (+) groups (all p values <0.05).
Infection with HBV may increase the serum concentrations of OPN. The association of OPN and HCC may be not attributable to tumor development per se but, rather, to HBV infection.
乙型肝炎病毒（HBV）感染者和肝细胞癌（HCC）患者的血清骨桥蛋白（OPN）浓度明显升高。
本研究旨在确定 HCC、OPN 和 HBV 之间的关系。
招募了 241 名受试者，并将其分为 6 组：健康对照组、无症状 HBsAg 携带者、HBsAg（-）伴其他肿瘤患者、HBsAg（+）慢性肝病患者、HBsAg（+）HCC 患者和 HBsAg（-）HCC 或肝硬化（LC）患者。检测并分析血清 OPN 和 HBsAg 浓度。
HBsAg（+）HCC 组的 OPN 浓度明显高于健康对照组和 HBsAg（-）伴其他癌症患者（均 p = 0.0001）。HBsAg（-）HCC 或 LC 患者的 OPN 浓度与健康对照组相比差异无统计学意义（p = 0.075）。所有 3 个 HBsAg（+）组中 HBsAg 滴度与 OPN 浓度均存在相关性（均 p 值<0.05）。
HBV 感染可能会增加血清 OPN 浓度。OPN 与 HCC 的相关性可能不是归因于肿瘤本身的发展，而是归因于 HBV 感染。
