Toronto General Hospital Research Institute, University Health Network, Toronto, Canada; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Canada; Heart & Stroke Richard Lewar Centre of Excellence in Cardiovascular Research, Toronto, Canada.
Heart & Stroke Richard Lewar Centre of Excellence in Cardiovascular Research, Toronto, Canada; Genetics and Genome Biology, Hospital for Sick Children, Toronto, Canada; Department of Molecular Genetics, University of Toronto, Toronto, Canada.
Trends Mol Med. 2017 Apr;23(4):332-347. doi: 10.1016/j.molmed.2017.02.004. Epub 2017 Mar 11.
Atherosclerosis is a vascular pathology characterized by inflammation and plaque build-up within arterial vessel walls. Vessel occlusion, often occurring after plaque rupture, can result in myocardial and cerebral infarction. Epigenetic changes are increasingly being associated with atherosclerosis and are of interest from both therapeutic and biomarker perspectives. Emerging genomic approaches that profile DNA methylation, chromatin accessibility, post-translational histone modifications, transcription factor binding, and RNA expression in low or single cell populations are poised to enhance our spatiotemporal understanding of atherogenesis. Here, we review recent therapeutically relevant epigenetic discoveries and emerging technologies that may generate new opportunities for atherosclerosis research.
动脉粥样硬化是一种血管病理学，其特征是动脉血管壁内的炎症和斑块形成。血管阻塞，通常在斑块破裂后发生，可导致心肌和脑梗死。越来越多的表观遗传变化与动脉粥样硬化有关，从治疗和生物标志物的角度来看都很有意义。新兴的基因组方法可以在低细胞或单细胞群体中对 DNA 甲基化、染色质可及性、转录后组蛋白修饰、转录因子结合和 RNA 表达进行分析，有望增强我们对动脉粥样硬化发病机制的时空理解。在这里，我们回顾了最近与治疗相关的表观遗传发现和新兴技术，这些发现和技术可能为动脉粥样硬化研究带来新的机会。
