Kattan Wae M Al, Alarfaj Seham F, Alnooh Bayan M, Alsaif Hadeel F, Alabdul Karim Hayfa S, Al-Qattan Noha M, Al-Qattan Mohammad M, El-Sayed Amel A F
Department of Surgery, Alfaisal University, Riyadh, Saudi Arabia.
Department of Surgery, King Saud University, Riyadh, Saudi Arabia.
J Coll Physicians Surg Pak. 2017 Jan;27(1):38-43.
Myofibroblast-mediated contraction is viewed as a cycle of four steps. The first step is stimulation of myofibroblasts by lysophospholipids leading to the activation of G proteins and ending with contraction of the actin-myosin complex. The next step is the transmission of the intracellular contractile force at the focal adhesions of myofibroblasts; a step that involves talin, vinculin, paxillin, Hic-5, and the integrin receptors. In the third step, fibronectin will act as the extracellular link between the integrin receptors and the extracellular collagen. Finally, "sensing" tension and the maintenance of myofibroblast activity represent the fourth step. The clinical relevance of each step is then discussed in the form of modalities to prevent excessive scarring/fibrosis.
肌成纤维细胞介导的收缩被视为一个由四个步骤组成的循环。第一步是溶血磷脂刺激肌成纤维细胞，导致G蛋白激活，最终使肌动蛋白-肌球蛋白复合体收缩。下一步是肌成纤维细胞粘着斑处细胞内收缩力的传递；这一步涉及踝蛋白、纽蛋白、桩蛋白、Hic-5和整合素受体。在第三步中，纤连蛋白将作为整合素受体与细胞外胶原蛋白之间的细胞外连接物。最后，“感知”张力和维持肌成纤维细胞活性代表第四步。然后以预防过度瘢痕形成/纤维化的方式讨论每个步骤的临床相关性。
