Hinz Boris, Gabbiani Giulio
Laboratory of Cell Biophysics, Swiss Federal Institute of Technology (EPFL), Bâtiment SG - AA-B 143, CH-1015 Lausanne, Switzerland.
Curr Opin Biotechnol. 2003 Oct;14(5):538-46. doi: 10.1016/j.copbio.2003.08.006.
The myofibroblast has been shown to have a key role in tissue reconstruction after injury and pathological changes characterized by fibrosis. Force generation by the myofibroblast depends on the isometric contraction of stress fibers containing alpha-smooth muscle actin, and is mediated through Rho/Rho-kinase. The force is transmitted by vinculin and tensin-containing "supermature" focal adhesions, which connect stress fibers with the extracellular matrix. Force production and transmission by the myofibroblast are modulated by the coordinated action of cytokines, extracellular matrix components and mechanical tension. Regulation of these phenomena will be important for therapeutic strategies aimed at influencing fibrocontractive diseases.
肌成纤维细胞已被证明在损伤后的组织重建以及以纤维化为特征的病理变化中起关键作用。肌成纤维细胞产生的力取决于含有α-平滑肌肌动蛋白的应力纤维的等长收缩，并通过Rho/ Rho激酶介导。该力由含纽蛋白和张力蛋白的“超成熟”粘着斑传递，这些粘着斑将应力纤维与细胞外基质相连。肌成纤维细胞产生和传递力受到细胞因子、细胞外基质成分和机械张力协同作用的调节。对这些现象的调控对于旨在影响纤维收缩性疾病的治疗策略至关重要。
