肥胖症的当前及未来医学治疗

Current and Future Medical Treatment of Obesity.

作者信息

Umashanker Devika, Igel Leon I, Kumar Rekha B, Aronne Louis J

机构信息

Comprehensive Weight Control Center, Division of Endocrinology, Diabetes, and Metabolism, Weill Cornell Medical College, 1165 York Avenue, New York, NY 10021, USA.

出版信息

Gastrointest Endosc Clin N Am. 2017 Apr;27(2):181-190. doi: 10.1016/j.giec.2016.12.008.

DOI:10.1016/j.giec.2016.12.008

PMID:28292399

Abstract

Obesity is a major health crisis resulting in comorbidities such as hypertension, type 2 diabetes, and obstructive sleep apnea. The need for safe and efficacious drugs to help assist with weight loss and reduce cardiometabolic risk factors is great. With several FDA-approved drugs on the market, there is still a great need to develop long-term obesity treatments or noninvasive oral agents to help assist individuals with obesity when used in conjunction with lifestyle modifications.

摘要

肥胖是一场重大的健康危机，会引发如高血压、2型糖尿病和阻塞性睡眠呼吸暂停等合并症。对于有助于减肥并降低心血管代谢风险因素的安全有效药物的需求很大。尽管市场上有几种已获美国食品药品监督管理局（FDA）批准的药物，但仍迫切需要开发长期肥胖治疗方法或非侵入性口服药物，以便在与生活方式改变相结合使用时帮助肥胖者。