脑肿瘤的微环境格局
The Microenvironmental Landscape of Brain Tumors.
作者信息
Quail Daniela F, Joyce Johanna A
机构信息
Goodman Cancer Research Centre, McGill University, Montreal, QC H3A 1A3, Canada; Department of Physiology, McGill University, Montreal, QC H3A 1A3, Canada.
Ludwig Institute for Cancer Research, University of Lausanne, 1066 Lausanne, Switzerland; Department of Oncology, University of Lausanne, Chemin des Boveresses 155, 1066 Lausanne, Switzerland.
出版信息
Cancer Cell. 2017 Mar 13;31(3):326-341. doi: 10.1016/j.ccell.2017.02.009.
Abstract
The brain tumor microenvironment (TME) is emerging as a critical regulator of cancer progression in primary and metastatic brain malignancies. The unique properties of this organ require a specific framework for designing TME-targeted interventions. Here, we discuss a number of these distinct features, including brain-resident cell types, the blood-brain barrier, and various aspects of the immune-suppressive environment. We also highlight recent advances in therapeutically targeting the brain TME in cancer. By developing a comprehensive understanding of the complex and interconnected microenvironmental landscape of brain malignancies we will greatly expand the range of therapeutic strategies available to target these deadly diseases.
摘要
脑肿瘤微环境（TME）正逐渐成为原发性和转移性脑恶性肿瘤中癌症进展的关键调节因子。该器官的独特特性需要一个特定的框架来设计针对TME的干预措施。在这里，我们讨论其中一些独特特征，包括脑内常驻细胞类型、血脑屏障以及免疫抑制环境的各个方面。我们还强调了在治疗上靶向癌症脑TME方面的最新进展。通过全面了解脑恶性肿瘤复杂且相互关联的微环境格局，我们将极大地扩展针对这些致命疾病的治疗策略范围。
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