Raj Resal, Bhatti Jasvinder Singh, Bhadada Sanjay Kumar, Ramteke Pramod W
Department of Computational Biology & Bioinformatics, Sam Higginbottom Institute of Agriculture, Technology and Sciences, Allahabad, UP, India.
Department of Biotechnology & Bioinformatics, SGGS College, Sector L26 Chandigarh, India.
Diabetes Metab Syndr. 2017 Nov;11 Suppl 1:S287-S293. doi: 10.1016/j.dsx.2017.03.004. Epub 2017 Mar 6.
Genetic variation of disease susceptible genes is different in different ethnic groups and there is an evidence of association of polymorphisms of Peroxisome Proliferator Activated Receptors (PPARs) in Type 2 Diabetes Mellitus (T2DM). This research analyses the association of PPARs in early and late onset of T2DM in North Indian Population (NIP).
Total of 703 subjects were recruited from north of India and subjects were further divided into subjects of early onset (less than 25 years of onset, 26 T2DM and 26 controls) and late onset (more than 25 years of onset, 326 T2DM and 325 controls).
The onset of T2DM begins from 15 years and continues further to maximum T2DM subjects to the age of 50 (76% of T2DM). High BMI and WHR, high blood pressure leading to early onset of hypertension, early mortality due to T2DM (7% of T2DM is above 75 years and 3% of T2DM has 20 years duration of onset) and high hyperglycemic NIP were the few outcomes of this research.
There is a strong association of PPAR γ, PPAR α and PPAR δ genes on the susceptibility of T2DM in late onset but not with the early onset of T2DM subjects in North Indian Population: Dual association of PPAR γ was observed with its genotype G/G (Ala/Ala) favoring protection against T2DM and genotype C/C (Pro/Pro) favoring susceptibility to T2DM. Association of intron7 polymorphism of PPAR α and +T294C polymorphism of PPAR δ on the susceptibility to T2DM requires further analysis.
疾病易感基因的遗传变异在不同种族群体中存在差异，并且有证据表明过氧化物酶体增殖物激活受体（PPARs）多态性与2型糖尿病（T2DM）有关。本研究分析了北印度人群（NIP）中PPARs与T2DM早发和晚发的关联。
从印度北部招募了703名受试者，并将其进一步分为早发组（发病年龄小于25岁，26例T2DM患者和26例对照）和晚发组（发病年龄大于25岁，326例T2DM患者和325例对照）。
T2DM发病始于15岁，并持续到50岁达到T2DM患者的最高比例（76%的T2DM患者）。高体重指数和腰臀比、高血压导致高血压早发、T2DM导致的早期死亡（7%的T2DM患者年龄在75岁以上，3%的T2DM患者发病持续20年）以及高血糖的北印度人群是本研究的部分结果。
在北印度人群中，PPARγ、PPARα和PPARδ基因与T2DM晚发的易感性密切相关，但与T2DM早发无关：观察到PPARγ的双重关联，其基因型G/G（Ala/Ala）有利于预防T2DM，而基因型C/C（Pro/Pro）则有利于T2DM的易感性。PPARα内含子7多态性和PPARδ +T294C多态性与T2DM易感性的关联需要进一步分析。
