过氧化物酶体增殖物激活受体δ +294T/C与体重指数的关联以及与过氧化物酶体增殖物激活受体α L162V的相互作用
Association of peroxisome proliferator-activated receptor delta +294T/C with body mass index and interaction with peroxisome proliferator-activated receptor alpha L162V.
作者信息
Aberle J, Hopfer I, Beil F U, Seedorf U
机构信息
Zentrum für Innere Medizin, Universitätsklinikum Hamburg-Eppendorf, Hamburg, Germany.
出版信息
Int J Obes (Lond). 2006 Dec;30(12):1709-13. doi: 10.1038/sj.ijo.0803345. Epub 2006 Apr 25.
OBJECTIVE
To investigate the association of a polymorphism at position 294 (+294T/C) in the Peroxisome Proliferator-activated Receptor delta (PPARdelta) with body mass index (BMI) and the additional role of a gene-to-gene interaction between PPARdelta, PPARalpha and PPARgamma.
DESIGN
An association between genetic variations in PPARdelta, PPARalpha and PPARgamma and indices of obesity and metabolism.
SUBJECTS
A group of 462 moderately obese (mean BMI 28.9+/-7.7) and dyslipidemic, middle-aged (mean age 43.9+/-13.7), Caucasion men and women.
MEASUREMENTS
The three most frequent single-nucleotide-polymorphisms (snp) in PPARdelta (+294T/C), PPARalpha (L162V) and PPARgamma (P12A) were genotyped and associated with clinical parameters.
RESULTS
The C allele in PPARdelta was significantly associated with a lower body mass index. Moreover an interaction between the polymorphisms in PPARalpha and PPARdelta on body weight could be demonstrated.
CONCLUSION
Our data provide further evidence for an involvement of PPARdelta in the regulation of BMI.
目的
研究过氧化物酶体增殖物激活受体δ（PPARδ）第294位（+294T/C）的多态性与体重指数（BMI）之间的关联，以及PPARδ、PPARα和PPARγ之间基因-基因相互作用的额外作用。
设计
PPARδ、PPARα和PPARγ的基因变异与肥胖和代谢指标之间的关联。
研究对象
一组462名中度肥胖（平均BMI 28.9±7.7）且血脂异常的中年（平均年龄43.9±13.7）白种男性和女性。
测量
对PPARδ（+294T/C）、PPARα（L162V）和PPARγ（P12A）中三种最常见的单核苷酸多态性（snp）进行基因分型，并与临床参数相关联。
结果
PPARδ中的C等位基因与较低的体重指数显著相关。此外，PPARα和PPARδ的多态性之间对体重的相互作用也得到了证实。
结论
我们的数据为PPARδ参与BMI调节提供了进一步的证据。
Zotero 插件