Aberle J, Hopfer I, Beil F U, Seedorf U
Zentrum für Innere Medizin, Universitätsklinikum Hamburg-Eppendorf, Hamburg, Germany.
Int J Obes (Lond). 2006 Dec;30(12):1709-13. doi: 10.1038/sj.ijo.0803345. Epub 2006 Apr 25.
To investigate the association of a polymorphism at position 294 (+294T/C) in the Peroxisome Proliferator-activated Receptor delta (PPARdelta) with body mass index (BMI) and the additional role of a gene-to-gene interaction between PPARdelta, PPARalpha and PPARgamma.
An association between genetic variations in PPARdelta, PPARalpha and PPARgamma and indices of obesity and metabolism.
A group of 462 moderately obese (mean BMI 28.9+/-7.7) and dyslipidemic, middle-aged (mean age 43.9+/-13.7), Caucasion men and women.
The three most frequent single-nucleotide-polymorphisms (snp) in PPARdelta (+294T/C), PPARalpha (L162V) and PPARgamma (P12A) were genotyped and associated with clinical parameters.
The C allele in PPARdelta was significantly associated with a lower body mass index. Moreover an interaction between the polymorphisms in PPARalpha and PPARdelta on body weight could be demonstrated.
Our data provide further evidence for an involvement of PPARdelta in the regulation of BMI.
研究过氧化物酶体增殖物激活受体δ（PPARδ）第294位（+294T/C）的多态性与体重指数（BMI）之间的关联，以及PPARδ、PPARα和PPARγ之间基因-基因相互作用的额外作用。
PPARδ、PPARα和PPARγ的基因变异与肥胖和代谢指标之间的关联。
一组462名中度肥胖（平均BMI 28.9±7.7）且血脂异常的中年（平均年龄43.9±13.7）白种男性和女性。
对PPARδ（+294T/C）、PPARα（L162V）和PPARγ（P12A）中三种最常见的单核苷酸多态性（snp）进行基因分型，并与临床参数相关联。
PPARδ中的C等位基因与较低的体重指数显著相关。此外，PPARα和PPARδ的多态性之间对体重的相互作用也得到了证实。
我们的数据为PPARδ参与BMI调节提供了进一步的证据。
