• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

The novel activation-induced deoxycytidine deaminase (AID) mutants, AIDv and AIDvΔ15 are defective in SHM and CSR.

作者信息

Kobayashi Maki, Takemoto Misao, Honjo Tasuku

机构信息

Department of Immunology and Genomic Medicine, Graduate School of Medicine, Kyoto University, Japan.

Department of Immunology and Genomic Medicine, Graduate School of Medicine, Kyoto University, Japan.

出版信息

DNA Repair (Amst). 2017 May;53:1-3. doi: 10.1016/j.dnarep.2017.02.015. Epub 2017 Mar 6.

DOI:10.1016/j.dnarep.2017.02.015
PMID:28292632
Abstract
摘要

相似文献

1
The novel activation-induced deoxycytidine deaminase (AID) mutants, AIDv and AIDvΔ15 are defective in SHM and CSR.新型激活诱导的胞嘧啶脱氨酶（AID）突变体AIDv和AIDvΔ15在体细胞高频突变（SHM）和类别转换重组（CSR）方面存在缺陷。
DNA Repair (Amst). 2017 May;53:1-3. doi: 10.1016/j.dnarep.2017.02.015. Epub 2017 Mar 6.
2
Isotype-switched follicular lymphoma displays dissociation between activation-induced cytidine deaminase expression and somatic hypermutation.同种型转换的滤泡性淋巴瘤在激活诱导的胞苷脱氨酶表达与体细胞超突变之间表现出解离。
Leuk Lymphoma. 2016;57(1):151-60. doi: 10.3109/10428194.2015.1037758. Epub 2015 May 18.
3
Activation induced cytidine deaminase mutant (AID-His130Pro) from Hyper IgM 2 patient retained mutagenic activity on SHM artificial substrate.来自高IgM 2型患者的激活诱导胞苷脱氨酶突变体（AID-His130Pro）在体细胞高频突变人工底物上保留诱变活性。
Mol Immunol. 2016 Nov;79:77-82. doi: 10.1016/j.molimm.2016.09.025. Epub 2016 Oct 4.
4
Activation-induced cytidine deaminase: structure-function relationship as based on the study of mutants.活化诱导的胞苷脱氨酶：基于突变体研究的结构-功能关系
Hum Mutat. 2006 Dec;27(12):1185-91. doi: 10.1002/humu.20414.
5
Separate domains of AID are required for somatic hypermutation and class-switch recombination.体细胞高频突变和类别转换重组需要AID的不同结构域。
Nat Immunol. 2004 Jul;5(7):707-12. doi: 10.1038/ni1086. Epub 2004 Jun 13.
6
Evolution of class switch recombination function in fish activation-induced cytidine deaminase, AID.鱼类激活诱导胞嘧啶脱氨酶（AID）中类别转换重组功能的演变
Int Immunol. 2006 Jan;18(1):41-7. doi: 10.1093/intimm/dxh347. Epub 2005 Nov 15.
7
Dissociation of in vitro DNA deamination activity and physiological functions of AID mutants.AID突变体的体外DNA脱氨基活性与生理功能的解离
Proc Natl Acad Sci U S A. 2008 Oct 14;105(41):15866-71. doi: 10.1073/pnas.0806641105. Epub 2008 Oct 2.
8
DNA targets of AID evolutionary link between antibody somatic hypermutation and class switch recombination.激活诱导胞嘧啶脱氨酶的DNA靶点：抗体体细胞高频突变与类别转换重组之间的进化联系
Adv Immunol. 2009;101:163-89. doi: 10.1016/S0065-2776(08)01005-5.
9
Activation-induced deaminase (AID)-directed hypermutation in the immunoglobulin Smu region: implication of AID involvement in a common step of class switch recombination and somatic hypermutation.激活诱导的胞嘧啶脱氨酶（AID）介导的免疫球蛋白Sμ区域高突变：AID参与类别转换重组和体细胞高频突变共同步骤的意义
J Exp Med. 2002 Feb 18;195(4):529-34. doi: 10.1084/jem.20012144.
10
Negative regulation of activation-induced cytidine deaminase in B cells.B细胞中活化诱导胞苷脱氨酶的负调控
Proc Natl Acad Sci U S A. 2006 Feb 21;103(8):2752-7. doi: 10.1073/pnas.0510970103. Epub 2006 Feb 13.

引用本文的文献

1
Cytoskeleton protein 4.1R regulates B-cell fate by modulating the canonical NF-κB pathway.细胞骨架蛋白 4.1R 通过调节经典 NF-κB 通路来调节 B 细胞命运。
Immunology. 2020 Dec;161(4):314-324. doi: 10.1111/imm.13250. Epub 2020 Sep 29.
2
Activation-induced deoxycytidine deaminase: Structural basis for favoring WRC hot motif specificities unique among APOBEC family members.激活诱导的胞苷脱氨酶：在载脂蛋白B mRNA编辑酶催化多肽样家族成员中独特偏好WRC热点基序特异性的结构基础。
DNA Repair (Amst). 2017 Jun;54:8-12. doi: 10.1016/j.dnarep.2017.03.007. Epub 2017 Mar 28.