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Activation-induced deoxycytidine deaminase: Structural basis for favoring WRC hot motif specificities unique among APOBEC family members.

作者信息

Pham Phuong, Afif Samir A, Shimoda Mayuko, Maeda Kazuhiko, Sakaguchi Nobuo, Pedersen Lars C, Goodman Myron F

机构信息

Department of Biological Sciences, University of Southern California, Los Angeles, CA 90089, United States.

Department of Immunology, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto 860-8556, Japan; Laboratory of Host Defence, Research Institute for Microbial Diseases, Osaka University, 3-1 Yamada-oka, Suita 565-0871, Japan; World Premier International Research Center Initiative, Immunology Frontier Research Center, Osaka University, 3-1 Yamada-oka, Suita 565-0871, Japan.

出版信息

DNA Repair (Amst). 2017 Jun;54:8-12. doi: 10.1016/j.dnarep.2017.03.007. Epub 2017 Mar 28.

DOI:10.1016/j.dnarep.2017.03.007
PMID:28388461
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6408873/
Abstract
摘要

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本文引用的文献

1
The novel activation-induced deoxycytidine deaminase (AID) mutants, AIDv and AIDvΔ15 are defective in SHM and CSR.新型激活诱导的胞嘧啶脱氨酶（AID）突变体AIDv和AIDvΔ15在体细胞高频突变（SHM）和类别转换重组（CSR）方面存在缺陷。
DNA Repair (Amst). 2017 May;53:1-3. doi: 10.1016/j.dnarep.2017.02.015. Epub 2017 Mar 6.
2
Structural basis for targeted DNA cytosine deamination and mutagenesis by APOBEC3A and APOBEC3B.载脂蛋白B mRNA编辑酶催化多肽样3A（APOBEC3A）和载脂蛋白B mRNA编辑酶催化多肽样3B（APOBEC3B）靶向DNA胞嘧啶脱氨和诱变的结构基础
Nat Struct Mol Biol. 2017 Feb;24(2):131-139. doi: 10.1038/nsmb.3344. Epub 2016 Dec 19.
3
Structural analysis of the activation-induced deoxycytidine deaminase required in immunoglobulin diversification.免疫球蛋白多样化所需的活化诱导的脱氧胞苷脱氨酶的结构分析
DNA Repair (Amst). 2016 Jul;43:48-56. doi: 10.1016/j.dnarep.2016.05.029. Epub 2016 May 13.
4
Activation-induced deoxycytidine deaminase (AID) co-transcriptional scanning at single-molecule resolution.单分子分辨率下激活诱导的胞嘧啶脱氨酶（AID）的共转录扫描
Nat Commun. 2015 Dec 18;6:10209. doi: 10.1038/ncomms10209.
5
A mathematical model for scanning and catalysis on single-stranded DNA, illustrated with activation-induced deoxycytidine deaminase.用于单链 DNA 扫描和催化的数学模型，以激活诱导的脱氧胞苷脱氨酶为例。
J Biol Chem. 2013 Oct 11;288(41):29786-95. doi: 10.1074/jbc.M113.506550. Epub 2013 Aug 26.
6
A biochemical analysis linking APOBEC3A to disparate HIV-1 restriction and skin cancer.一种将 APOBEC3A 与不同的 HIV-1 限制和皮肤癌联系起来的生化分析。
J Biol Chem. 2013 Oct 11;288(41):29294-304. doi: 10.1074/jbc.M113.504175. Epub 2013 Aug 26.
7
APOBEC3B is an enzymatic source of mutation in breast cancer.APOBEC3B 是乳腺癌突变的酶源。
Nature. 2013 Feb 21;494(7437):366-70. doi: 10.1038/nature11881. Epub 2013 Feb 6.
8
Biochemical analysis of hypermutation by the deoxycytidine deaminase APOBEC3A.APOBEC3A 脱氨酶的超突变的生化分析。
J Biol Chem. 2012 Aug 31;287(36):30812-22. doi: 10.1074/jbc.M112.393181. Epub 2012 Jul 20.
9
A structural basis for the biochemical behavior of activation-induced deoxycytidine deaminase class-switch recombination-defective hyper-IgM-2 mutants.激活诱导的脱氧胞苷脱氨酶类转换重组缺陷性高 IgM-2 突变体的生化行为的结构基础。
J Biol Chem. 2012 Aug 10;287(33):28007-16. doi: 10.1074/jbc.M112.370189. Epub 2012 Jun 19.
10
Analysis of a single-stranded DNA-scanning process in which activation-induced deoxycytidine deaminase (AID) deaminates C to U haphazardly and inefficiently to ensure mutational diversity.分析单链 DNA 扫描过程，在此过程中，激活诱导的脱氨酶（AID）随机且低效地将 C 脱氨为 U，以确保突变多样性。
J Biol Chem. 2011 Jul 15;286(28):24931-42. doi: 10.1074/jbc.M111.241208. Epub 2011 May 12.