Radzikowski Jakub Leszek, Schramke Hannah, Heinemann Matthias
Molecular Systems Biology, Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, Nijenborgh 4, 9747 AG Groningen, The Netherlands.
Molecular Systems Biology, Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, Nijenborgh 4, 9747 AG Groningen, The Netherlands.
Curr Opin Biotechnol. 2017 Aug;46:98-105. doi: 10.1016/j.copbio.2017.02.012. Epub 2017 Mar 11.
In recent years, our understanding about bacterial persistence has significantly advanced: we comprehend the persister phenotype better, more triggers for persistence entry have been found, and more insights in the involvement and role of toxin-antitoxin systems and other molecular mechanisms have been unravelled. In this review, we attempt to put these findings into an integrated, system-level perspective. From this point of view, persistence can be seen as a response to a strong perturbation of metabolic homeostasis, either triggered environmentally, or by means of intracellular stochasticity. Metabolic-flux-regulated resource allocation ensures stress protection, and several feedback mechanisms stabilize the cells in this protected state. We hope that this novel view can advance our understanding about persistence.
近年来，我们对细菌持留性的理解有了显著进展：我们对持留菌表型有了更好的理解，发现了更多诱导进入持留状态的触发因素，并且对毒素-抗毒素系统及其他分子机制的参与情况和作用有了更多认识。在本综述中，我们试图将这些发现置于一个综合的系统层面视角中。从这个角度来看，持留性可被视为对代谢稳态强烈扰动的一种反应，这种扰动要么由环境触发，要么通过细胞内的随机性产生。代谢通量调节的资源分配确保了应激保护，并且几种反馈机制使细胞在这种受保护状态下保持稳定。我们希望这种新观点能够增进我们对持留性的理解。
