Wickner William, Rizo Josep
Department of Biochemistry and Cell Biology, Geisel School of Medicine at Dartmouth, Hanover, NH 03755
Departments of Biophysics, Biochemistry, and Biophysics, University of Texas Southwestern Medical Center, Dallas, TX 75390
Mol Biol Cell. 2017 Mar 15;28(6):707-711. doi: 10.1091/mbc.E16-07-0517.
Recent studies suggest revisions to the SNARE paradigm of membrane fusion. Membrane tethers and/or SNAREs recruit proteins of the Sec 1/Munc18 family to catalyze SNARE assembly into -complexes. SNARE-domain zippering draws the bilayers into immediate apposition and provides a platform to position fusion triggers such as Sec 17/α-SNAP and/or synaptotagmin, which insert their apolar "wedge" domains into the bilayers, initiating the lipid rearrangements of fusion.
最近的研究表明需要对膜融合的SNARE模式进行修正。膜系链和/或SNARE招募Sec 1/Munc18家族的蛋白质来催化SNARE组装成复合物。SNARE结构域的拉链作用将双层膜拉近并提供一个平台来定位融合触发因子，如Sec 17/α-SNAP和/或突触结合蛋白，它们将其非极性“楔形”结构域插入双层膜中，启动融合的脂质重排。
